61650-68-8

Basic information

• Product Name: 7-hydroxy-6-deoxy-6-demethyltetracycline
• Synonyms: 7-hydroxy-6-deoxy-6-demethyltetracycline
• CAS NO: 61650-68-8
• Molecular Weight: 430.414
• Mol File: 61650-68-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-hydroxy-6-deoxy-6-demethyltetracycline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-6-deoxy-6-demethyltetracycline(61650-68-8)
• EPA Substance Registry System: 7-hydroxy-6-deoxy-6-demethyltetracycline(61650-68-8)

Safety Data

• Hazardous Substances Data: 61650-68-8(Hazardous Substances Data)

Relevant articles and documents

SEMI-SYNTHESIS PROCEDURES

Provided herein are improved processes tor convening C7-amino-substituted tetracyclines to C7-fluoro-substituted tetracyclines, as well as intermediates produced by or used in these processes. In one embodiment, a thermal fluorination method is provided in which a suspension comprising a non-polar organic solvent and a C7-diazo-substituted tetracycline hexafluorophosphate, hexafluoarsenate or hexafluorosilicate salt, or a salt, solvate or combination thereof, is healed to provide a C7-fluoro-substituted tetracycline, or salt, solvate or combination thereof. In another embodiment, a photolytic fluorination is provided in which a solution comprising an ionic liquid and a C-7diazo-substituted tetracycline tetrafluoroborate, hexafluorophosphate, hexafluoroarsenate or hexafluorosilicate salt, or a salt, solvate or combination thereof, is irradiated to provide a C7-fluoro-substituted tetracycline, or salt, solvate or combination thereof.