614-69-7 Usage
Description
2-Methylphenyl isothiocyanate, also known as o-isothiocyanatotoluene, is an organic compound with the chemical formula C8H7NS. It is a clear yellow liquid at room temperature and possesses a characteristic pungent odor. 2-Methylphenyl isothiocyanate is derived from the reaction of 2-methylaniline with isothiocyanate, and it is known for its chemical reactivity and potential applications in various industries.
Uses
Used in Surfactants:
2-Methylphenyl isothiocyanate is used as an additive in the surfactant industry to enhance the performance of surfactants. Its incorporation improves the wetting, emulsifying, and foaming properties of surfactants, making them more effective in various applications such as detergents, cleaners, and personal care products.
Used in Films and Resins:
2-Methylphenyl isothiocyanate is also utilized as a component in the production of films and resins. Its presence in these materials contributes to improved mechanical properties, such as tensile strength and flexibility, as well as enhanced resistance to environmental factors like heat, light, and moisture.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Methylphenyl isothiocyanate is used as an intermediate in the synthesis of various therapeutic agents. Its unique chemical structure allows for the development of new drugs with potential applications in treating various diseases and medical conditions.
Used in Agrochemicals:
2-Methylphenyl isothiocyanate is employed in the agrochemical industry as a building block for the synthesis of pesticides and other crop protection agents. Its incorporation into these products helps to improve their effectiveness in controlling pests and diseases, ultimately leading to increased crop yields and better food security.
Used in Dyes and Pigments:
2-Methylphenyl isothiocyanate is also used in the production of dyes and pigments due to its intense color and stability. Its application in this industry contributes to the development of high-quality colorants for various applications, such as textiles, plastics, and printing inks.
Check Digit Verification of cas no
The CAS Registry Mumber 614-69-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 614-69:
(5*6)+(4*1)+(3*4)+(2*6)+(1*9)=67
67 % 10 = 7
So 614-69-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NS/c1-7-4-2-3-5-8(7)9-6-10/h2-5H,1H3
614-69-7Relevant articles and documents
A catalyst-free method for the synthesis of 1,4,2-dithiazoles from isothiocyanates and hydroxylamine triflic acid salts
An, Zhenyu,Liu, Yafeng,Ren, Yi,Wang, Ting,Yan, Rulong
supporting information, p. 6206 - 6209 (2021/07/28)
A catalyst-free method for the preparation of 1,4,2-dithiazoles is developed by reactions of isothiocyanates with hydroxylamine triflic acid salts. This reaction achieves C-S, C-N, and S-N bond formation, and a range of products are obtained in moderate to good yields. The obvious feature is using shelf-stable hydroxylamine triflic acid salts as a N source to synthesize heterocycles under mild conditions.
Diaryl-substituted thiosemicarbazone: A potent scaffold for the development of New Delhi metallo-β-lactamase-1 inhibitors
Li, Jia-Qi,Sun, Le-Yun,Jiang, Zhihui,Chen, Cheng,Gao, Han,Chigan, Jia-Zhu,Ding, Huan-Huan,Yang, Ke-Wu
, (2020/12/30)
The superbug infection caused by New Delhi metallo-β-lactamase (NDM-1) has become an emerging public health threat. Inhibition of NDM-1 has proven challenging due to its shuttling between pathogenic bacteria. A potent scaffold, diaryl-substituted thiosemicarbazone, was constructed and assayed with metallo-β-lactamases (MβLs). The obtained twenty-six molecules specifically inhibited NDM-1 with IC50 0.038–34.7 μM range (except 1e, 2e, and 3d), and 1c is the most potent inhibitor (IC50 = 0.038 μM). The structure-activity relationship of synthetic thiosemicarbazones revealed that the diaryl-substitutes, specifically 2-pyridine and 2-hydroxylbenzene improved inhibitory activities of the inhibitors. The thiosemicarbazones exhibited synergistic antimycobacterial actions against E. coli-NDM-1, resulted a 2–512-fold reduction in MIC of meropenem, while 1c restored 16–256-, 16-, and 2-fold activity of the antibiotic on clinical isolates ECs, K. pneumonia and P. aeruginosa harboring NDM-1, respectively. Also, mice experiments showed that 1c had a synergistic antibacterial ability with meropenem, reduced the bacterial load clinical isolate EC08 in the spleen and liver. This work provided a highly promising scaffold for the development of NDM-1 inhibitors.
