6138-41-6 Usage
Description
Trigonelline hydrochloride, also known as N-methylnicotinic acid betaine hydrochloride, is a betaine type pyrimidine alkaloid that is found in various seeds, including coffee beans. It is synthesized from nicotinic acid in many plant species and has been reported to possess diverse biological activities, such as hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities. Trigonelline is also a product of niacin metabolism that is excreted in urine.
Uses
Used in Pharmaceutical Industry:
Trigonelline hydrochloride is used as a pharmaceutical agent for its diverse biological activities. It is used for its hypoglycemic effects to help manage blood sugar levels, hypolipidemic properties to reduce lipid levels in the blood, and neuroprotective actions to protect the nervous system.
Trigonelline hydrochloride is also used as an antimigraine agent to alleviate the symptoms of migraines, a sedative to promote relaxation and sleep, and a memory-improving agent to enhance cognitive function.
Used in Antimicrobial Applications:
In the field of antimicrobial applications, trigonelline hydrochloride is used as an antibacterial agent to combat bacterial infections and as an antiviral agent to fight against viral infections.
Used in Anticancer Applications:
Trigonelline hydrochloride is used as an anti-tumor agent in cancer research, exhibiting potential anti-tumor activities that can be explored for the development of novel cancer therapies.
Used in Coffee Industry:
In the coffee industry, trigonelline hydrochloride is found in coffee beans and may contribute to the unique flavor and health benefits associated with coffee consumption.
References
Trigonelline: a plant alkaloid with therapeutic potential for diabetes and central nervous system disease (a review)J. Zhou, L. Chan, S. Zhou, Curr. Med. Chem. 2012, 19, 3523.A Review on Biosynthesis, Analytical Techniques, and Pharmacological Activities of Trigonelline as a Plant AlkaloidN. Mohamadi, F. Sharififar, M. Pournamdari, M. Ansari, J. Dietary Suppl. 2018, 15, 207.
Check Digit Verification of cas no
The CAS Registry Mumber 6138-41-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,3 and 8 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6138-41:
(6*6)+(5*1)+(4*3)+(3*8)+(2*4)+(1*1)=86
86 % 10 = 6
So 6138-41-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H7NO2.ClH/c1-8-4-2-3-6(5-8)7(9)10;/h2-5H,1H3;1H
6138-41-6Relevant articles and documents
PHARMACEUTICAL COMPOSITION AND A PROCESS THEREOF
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Page/Page column 6-7, (2008/12/08)
The present invention relates to a pharmaceutical composition having dopaminergic activity and other related pharmaceutical activities comprising trigonelline or its derivative(s) and 4-hydroxyisoleucine or its derivative(s), optionally along with excipients(s); a process of preparing a pharmaceutical composition comprising trigonelline or its derivative(s) and 4-hydroxyisoleucine or its derivative(s), optionally along with excipients(s), wherein the process comprising steps of: (a) extracting a clear solution containing trigonelline and 4-hydroxyisoleucine from plant source; and (b) optionally precipitating derivative(s) of trigonelline and 4-hydroxyisoleucine from the clear solution and obtaining said composition; and an in-vitro method to increase levels of dopamine or to inhibit prolactin by allowing composition comprising trigonelline or its derivative(s) and 4-hydroxyisoleucine or its derivative(s) to bind to cell receptors.
