613-84-3 Usage
Description
5-Methylsalicylaldehyde, also known as 2-Hydroxy-5-methylbenzaldehyde, is an organic compound with the chemical formula C8H8O2. It is a derivative of salicylic aldehyde, featuring a methyl group attached to the 5th position of the benzene ring. 5-Methylsalicylaldehyde is known for its potential applications in medicinal chemistry and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
5-Methylsalicylaldehyde is used as a key intermediate in the synthesis of novel 2-Phenylcyclopropanamine derivatives. These derivatives serve as Lysine-specific Demethylase 1 inhibitors (LSD1-inhibitors), which are of significant interest in the prevention or treatment of primary brain tumors. By targeting LSD1, these inhibitors can potentially regulate gene expression and cellular processes, offering a promising therapeutic approach for brain cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 613-84-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 613-84:
(5*6)+(4*1)+(3*3)+(2*8)+(1*4)=63
63 % 10 = 3
So 613-84-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O2/c1-6-2-3-8(10)7(4-6)5-9/h2-5,10H,1H3
613-84-3Relevant articles and documents
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Yaroslavsky
, p. 1503 (1965)
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Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: Access to the synthesis of chromeno[4,3-: B] pyrroles
Huang, You,Li, Xiaohu
supporting information, p. 9934 - 9937 (2021/10/12)
A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.
Highly practical and efficient preparation of aldehydes and ketones from aerobic oxidation of alcohols with an inorganic-ligand supported iodine catalyst
Zhang, Mengqi,Zhai, Yongyan,Ru, Shi,Zang, Dejin,Han, Sheng,Yu, Han,Wei, Yongge
supporting information, p. 10164 - 10167 (2018/09/13)
Herein, we divulge an efficient protocol for aerobic oxidation of alcohols with an inorganic-ligand supported iodine catalyst, (NH4)5[IMo6O24]. The catalyst system is compatible with a wide range of groups and exhibits high selectivity, and shows excellent stability and reusability, thus serving as a potentially greener alternative to the classical transformations.