61109-48-6

Basic information

• Product Name: 1-Naphthalenecarboxylic acid, 6-methoxy-, methyl ester
• Synonyms: 6-methoxy-[1]naphthoic acid methyl ester;1-Naphthalenecarboxylic acid,6-methoxy-,methyl ester;METHYL 6-METHOXY-1-NAPHTHOATE;methyl 6-methoxynaphthoate;methyl 6-methoxy-1-naphthalenecarboxylate;6-methoxy-1-naphthalenecarboxylic acid methyl ester;6-Methoxy-[1]naphthoesaeure-methylester
• CAS NO: 61109-48-6
• Molecular Formula: C13H12O3
• Molecular Weight: 216.236
• Mol File: 61109-48-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 344.1±15.0 °C(Predicted)
• Density: 1.166±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Naphthalenecarboxylic acid, 6-methoxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Naphthalenecarboxylic acid, 6-methoxy-, methyl ester(61109-48-6)
• EPA Substance Registry System: 1-Naphthalenecarboxylic acid, 6-methoxy-, methyl ester(61109-48-6)

Safety Data

• Hazardous Substances Data: 61109-48-6(Hazardous Substances Data)

Upstream product

• 84532-70-7 methyl 6-methoxy-5-bromo-1-naphthoate 
• 67-56-1 methanol 
• 5289-78-1 3-methoxy-1,8-naphthalic anhydride 
• 2437-17-4 6-hydroxy-1-naphthoic acid 
• 74-88-4 methyl iodide 
• 56578-36-0 (E)-m-methoxycinnamaldehyde 
• 16141-78-9 methyl 2-dimethoxyphosphoryl-2-methoxyacetate 
• 36112-61-5 6-methoxy-1-naphthoic acid 
• 77-78-1 dimethyl sulfate 
• 90162-13-3 methyl 6-hydroxy-1-naphthoate 
• 88-14-2 2-furanoic acid 
• 2437-18-5 5-hydroxy-2-naphthoic acid 
• 5043-31-2 5-Methoxy-2-naphthoic acid 
• 100-66-3 methoxybenzene 

Downstream Products

• 388622-50-2 5-fluoro-1,6-dihydroxynaphthalene 
• 3597-42-0 6-methoxy-1-naphthalaldehyde 
• 58149-89-6 1-(6-methoxynaphthalen-1-yl)ethanone 
• 61109-50-0 2-(6-Methoxy-naphthalen-1-ylmethyl)-2-methyl-cyclohexane-1,3-dione 
• 84532-72-9 6-methoxy-5-(trifluoromethyl)-1-naphthalenecarboxylic acid 
• 120522-86-3 tolrestat 
• 478157-75-4 1-[2-(2-iodo-phenyl)-allyl]-6-methoxy-1,4-dihydro-naphthalene-1-carboxylic acid methyl ester 
• 388622-47-7 methyl 5-fluoro-6-hydroxy-1-naphthalenecarboxylate 
• 388622-46-6 methyl 5-fluoro-6-methoxy-1-naphthoate 

Relevant articles and documents

Pd-catalyzed allylative dearomatisation using Grignard reagents

Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions.

Ipso- borylation of aryl ethers via Ni-Catalyzed C-OMe Cleavage

A Ni-catalyzed ipso-borylation of aryl ethers via C(sp2)-OMe and C(sp3)-OMe cleavage is described. The transformation is characterized by its wide substrate scope under mild conditions and an exquisite divergence in site selectivity that can be easily switched by selecting the appropriate boron reagent.

Asymmetric transfer hydrogenation of 1-naphthyl ketones by an ansa-Ru(II) complex of a DPEN-SO2N(Me)-(CH2)2(η 6-p-tol) combined ligand

The first second-generation designer Ru(II) catalyst 1b featuring an enantiopure N,C-(N-ethylene-N-methyl-sulfamoyl)-tethered (DPEN- κ2N,N′)/η6-toluene hybrid ligand is introduced. Using an S/C = 1000 in HCO2H-Et3N 5:2 transfer hydrogenation medium, secondary 1-naphthyl alcohols are obtained in up to >99.9% ee under mild conditions. Mechanistic factors are discussed.