61-56-3 Usage
Description
Sultiame, also known as Sulthiame, is a benzenesulfonamide derivative that acts as an inhibitor of the enzyme carbonic anhydrase. It is characterized by its off-white solid appearance and is recognized for its effectiveness in the treatment of certain neurological conditions.
Uses
Used in Pharmaceutical Industry:
Sultiame is used as an anticonvulsant for the treatment of benign and symptomatic focal epilepsy. It helps in managing seizures by inhibiting the enzyme carbonic anhydrase, which plays a role in the development of epileptic seizures.
Brand Names:
Sultiame is available under the brand names Conadil (3M Pharmaceuticals) and Trolone (3M Pharmaceuticals), making it accessible to patients in need of anticonvulsant medication.
Check Digit Verification of cas no
The CAS Registry Mumber 61-56-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 61-56:
(4*6)+(3*1)+(2*5)+(1*6)=43
43 % 10 = 3
So 61-56-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)
61-56-3Relevant articles and documents
Enantioselective Hydroamination of Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer
Demaerel, Joachim,Graff, David E.,Knowles, Robert R.,Roos, Casey B.
supporting information, p. 5974 - 5979 (2020/04/27)
An enantioselective, radical-based method for the intramolecular hydroamination of alkenes with sulfonamides is reported. These reactions are proposed to proceed via N-centered radicals formed by proton-coupled electron transfer (PCET) activation of sulfonamide N-H bonds. Noncovalent interactions between the neutral sulfonamidyl radical and a chiral phosphoric acid generated in the PCET event are hypothesized to serve as the basis for asymmetric induction in a subsequent C-N bond forming step, achieving selectivities of up to 98:2 er. These results offer further support for the ability of noncovalent interactions to enforce stereoselectivity in reactions of transient and highly reactive open-shell intermediates.
