60784-46-5 Usage
Description
Elmustine, also known as Altretamine, is an antineoplastic drug that belongs to the class of nitrosoureas. It is a synthetic compound with a chemical structure that allows it to cross-link DNA, leading to the disruption of cellular replication and ultimately causing cell death. Elmustine is particularly effective against various types of cancer due to its ability to interfere with the cancer cell's DNA synthesis and repair mechanisms.
Uses
Used in Anticancer Applications:
Elmustine is used as an antitumor agent for its ability to inhibit human glutathione reductase, a key enzyme involved in cellular defense mechanisms against oxidative stress. By targeting this enzyme, elmustine enhances the effectiveness of other chemotherapy drugs and helps in the treatment of various types of cancer, including breast cancer, ovarian cancer, and colorectal cancer.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, elmustine is used as an active pharmaceutical ingredient (API) in the development of cancer treatment drugs. Its unique mechanism of action and effectiveness against a range of cancers make it a valuable component in the fight against cancer. Additionally, research is ongoing to explore its potential synergistic effects when combined with other chemotherapeutic agents, aiming to improve treatment outcomes and overcome drug resistance in cancer patients.
Check Digit Verification of cas no
The CAS Registry Mumber 60784-46-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,7,8 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 60784-46:
(7*6)+(6*0)+(5*7)+(4*8)+(3*4)+(2*4)+(1*6)=135
135 % 10 = 5
So 60784-46-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H10ClN3O3/c6-1-3-9(8-12)5(11)7-2-4-10/h10H,1-4H2,(H,7,11)
60784-46-5Relevant articles and documents
1,2,2,2-Tetrachloroethyl Carbamates: Versatile Intermediates for the Synthesis of N-Nitrosoureas
Barcelo, Gerard,Senet, Jean-Pierre,Sennyey, Gerard
, p. 1027 - 1029 (2007/10/02)
1,2,2,2-Tetrachloroethyl carbamates 3 were prepared by the reaction of 1,2,2,2-tetrachloroethyl carbonochloridate with amines.Carbamates 3 were then nitrosated and reacted with amines to yield N-nitrosoureas.
