60755-80-8 Usage
Description
O-DESMETHYLGALANTHAMINE is a natural alkaloid compound that is closely related to galanthamine. It possesses acetylcholinesterase inhibitory activity, making it a potential candidate for the treatment of neurodegenerative diseases, particularly Alzheimer's disease.
Used in Pharmaceutical Industry:
O-DESMETHYLGALANTHAMINE is used as an acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Its inhibitory activity is more potent than that of galanthamine, making it a promising candidate for the development of new therapeutic agents.
Used in Research Applications:
O-DESMETHYLGALANTHAMINE is used as a research tool for studying the mechanisms of acetylcholinesterase inhibition and the development of new drugs targeting this enzyme. Its selectivity for acetylcholinesterase over butyrylcholinesterase makes it a valuable compound for investigating the specific actions of these enzymes in neurodegenerative diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 60755-80-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,7,5 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 60755-80:
(7*6)+(6*0)+(5*7)+(4*5)+(3*5)+(2*8)+(1*0)=128
128 % 10 = 8
So 60755-80-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H19NO3/c1-17-7-6-16-5-4-11(18)8-13(16)20-15-12(19)3-2-10(9-17)14(15)16/h2-5,11,13,18-19H,6-9H2,1H3/t11-,13-,16-/m0/s1
60755-80-8Relevant articles and documents
Synthesis of deuterium-labelled (-)-galanthamine
Rouleau, Julien,Guillou, Catherine
, p. 236 - 238 (2008/12/20)
The synthesis of deuterium-labelled galanthamine is reported. 6-[ 2H3]methoxy-N-[2H3]methyl-(-)- galanthamine was obtained in seven steps from galanthamine. The synthesis was carried out by selective O- and N-de
Potent acetylcholinesterase inhibitors: Design, synthesis, and structure - Activity relationships of bis-interacting ligands in the galanthamine series
Mary, Aude,Renko, Dolor Zafiarisoa,Guillou, Catherine,Thal, Claude
, p. 1835 - 1850 (2007/10/03)
New galanthamine derivatives, especially bis-interacting ligands 3-5 and 7-9 were prepared in order to interact with the catalytic and the peripheral sites of acetylcholinesterase (AChE). The synthesis, the anticholinesterase activities, and the structure-activity relationships of bis-interacting ligands are reported. Compounds 4d-e were found to be more potent than galanthamine and tacrine in inhibiting AChE. Copyright (C) 1998 Elsevier Science Ltd.
