606143-46-8

Basic information

• Product Name: Methyl 6-(4-broMo-2-chlorophenylaMino)-7-fluoro-1H-benzo[d]iMidazole-5-carboxylate
• Synonyms: Methyl 6-(4-broMo-2-chlorophenylaMino)-7-fluoro-1H-benzo[d]iMidazole-5-carboxylate;methyl 5-(4-bromo-2-chlorophenylamino)-4-fluoro-1H-benzo[d]imidazole-6-carboxylate
• CAS NO: 606143-46-8
• Molecular Formula: C₁₅H₁₀BrClFN₃O₂
• Molecular Weight: 398.6142032
• Mol File: 606143-46-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 539.0±50.0 °C(Predicted)
• Appearance: /
• Density: 1.722±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.14±0.30(Predicted)
• CAS DataBase Reference: Methyl 6-(4-broMo-2-chlorophenylaMino)-7-fluoro-1H-benzo[d]iMidazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-(4-broMo-2-chlorophenylaMino)-7-fluoro-1H-benzo[d]iMidazole-5-carboxylate(606143-46-8)
• EPA Substance Registry System: Methyl 6-(4-broMo-2-chlorophenylaMino)-7-fluoro-1H-benzo[d]iMidazole-5-carboxylate(606143-46-8)

Safety Data

• Hazardous Substances Data: 606143-46-8(Hazardous Substances Data)

Usage

General Description

Methyl 6-(4-bromo-2-chlorophenylamino)-7-fluoro-1H-benzo[d]imidazole-5-carboxylate is a complex organic compound that belongs to the category of benzimidazoles, which consist of a benzene ring fused to an imidazole ring. It is characterized by the presence of multiple functional groups including a methyl ester group (-COOCH3), amino group (-NH2), bromo (-Br) and chloro (-Cl) substituents. The presence of a fluorine atom (-F) further adds to the complexity of the molecule. This chemical, due to its intricate chemical structure, may be of interest in various chemical research and pharmaceutical applications, although its specific uses and properties need further exploration. Its IUPAC name, molecular weight, and other intrinsic properties can be calculated based on its structural formula.

Upstream product

• 606093-59-8 7-Fluoro-6-phenylamino-3H-benzoimidazole-5-carboxylic acid methyl ester 
• 606144-42-7 4,5-diamino-3-fluoro-2-phenylamino-benzoic acid methyl ester 
• 606093-58-7 4-Amino-3-fluoro-5-nitro-2-phenylamino-benzoic acid methyl ester 
• 284030-58-6 4-Amino-2,3-difluoro-5-nitro-benzoic acid methyl ester 
• 284030-57-5 4-amino-2,3-difluoro-5-nitro-benzoic acid 
• 197520-71-1 2,3,4-trifluoro-5-nitro-benzoic acid 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 

Downstream Products

• 606144-01-8 6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid 
• 606144-04-1 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid 
• 606144-02-9 methyl 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate 
• 606144-11-0 6-(4-Bromo-2-chloro-phenylamino)-3-(2-tert-butoxycarbonyl-ethyl)-7-fluoro-3H-benzoimidazole-5-carboxylic acid methyl ester 
• 606144-03-0 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester 

Relevant articles and documents

Substituted benzimidazole compound and composition with compound

The invention provides a substituted benzimidazole compound and a composition with the compound. The substituted benzimidazole compound is a compound of formula (I) as shown in the specification, or apharmaceutically acceptable salt, prodrug, aquo-complex or solvent compound, polycrystalline type compound, stereisomer or isotope variant of the compound. The compound provided by the invention canbe adopted to treat and/or prevent related diseases caused by MEK (Methyl Ethyl Ketone), such as excessive proliferative diseases, pancreatitis, kidney illness, blastocyte cell transplantation and angiogenesis or angiopoiesis related diseases.

N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS

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