60612-23-9

Basic information

• Product Name: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE
• Synonyms: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HCL;N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE;N-[(2-chlorophenyl)methyl]thiophene-2-ethylamine hydrochloride;N-(2-Chlorobenzyl)-2-(-2-thienty)ethylamine Hydrochloride
• CAS NO: 60612-23-9
• Molecular Formula: C₁₃H₁₄ClNS*ClH
• Molecular Weight: 288.24
• EINECS: 262-327-7
• Mol File: 60612-23-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 143 °C
• Boiling Point: 359.9°C at 760 mmHg
• Flash Point: 171.5°C
• Appearance: /
• Vapor Pressure: 2.3E-05mmHg at 25°C
• CAS DataBase Reference: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE(60612-23-9)
• EPA Substance Registry System: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE(60612-23-9)

Safety Data

• Hazardous Substances Data: 60612-23-9(Hazardous Substances Data)

Usage

Description

N-(2-Chlorobenzyl)-2-(2-thienyl)ethylamine hydrochloride is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes a chlorobenzyl group and a thienylethylamine moiety, and is typically presented in its hydrochloride salt form.

Uses

Used in Pharmaceutical Industry:
N-(2-Chlorobenzyl)-2-(2-thienyl)ethylamine hydrochloride is used as a key intermediate in the preparation of acid addition salts of 4,5,6,7-tetrahydrothieno(3,2-c)pyridine derivatives. These derivatives possess significant antithrombotic activity, making them valuable in the development of medications aimed at preventing blood clot formation and related thrombotic disorders.
N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE's role in the synthesis of antithrombotic agents underscores its importance in the pharmaceutical sector, where it contributes to the creation of life-saving drugs that can help manage and treat cardiovascular conditions. Its application in this context highlights the significance of organic chemistry in advancing modern medicine and improving patient outcomes.

InChI:InChI=1/C13H14ClNS.ClH/c14-13-6-2-1-4-11(13)10-15-8-7-12-5-3-9-16-12;/h1-6,9,15H,7-8,10H2;1H

Upstream product

• 5402-55-1 2-thiophenethanol 
• 40412-06-4 2-(2-thienyl)ethyl tosylate 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 75-21-8 oxirane 
• 98-59-9 p-toluenesulfonyl chloride 
• 2786-07-4 2-thienyl lithium 
• 143810-09-7 N-(2-chlorobenzyl)-2,2-dioxo-1,2,3-oxathiazolidine 

Downstream Products

• 53885-35-1 ticlopidine hydrochloride 

Relevant articles and documents

Novel preparation method for ticlopidine hydrochloride

The invention provides a novel preparation method for ticlopidine hydrochloride. The method comprises the following steps: with thiopheneethanol as a raw material, reacting thiopheneethanol with p-toluene sulfonyl chloride under the action of an acid binding agent so as to protect and activate a hydroxyl group; then subjecting a reaction product obtained in the previous step and o-chlorobenzylamine to a condensation reaction; and carrying out a ring closure reaction on a condensation reaction product and 1,3-dioxolane so as to obtain ticlopidine hydrochloride. The novel preparation method has the advantages of mild reaction conditions, low production cost, high product yield, good product quality and easy realization of industrial production.

Method for preparing ticlopidine hydrochloride

The invention provides a method for preparing ticlopidine hydrochloride, which comprises the following steps: reacting thienyl ethanol used as a raw material with paratoluensulfonyl chloride under the action of an acid-binding agent to protect and activate the hydroxy group; carrying out condensation reaction with ortho-chlorobenzylamine; and carrying out cyclization reaction with 1,3-dioxolane under acidic conditions to obtain the ticlopidine hydrochloride. The method has the advantages of mild reaction conditions, low production cost, high product yield and good product quality, and is convenient for industrial production.

N-2-chlorobenzyl-2-oxo and N-2-chlorobenzyl-2,2-dioxo-1,2,3-oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2-c]pyridine derivatives therefrom

Compounds of the formula: STR1 wherein: A is oxo or dioxo; R1, R2 and R3 are independently hydrogen or lower alkyl of one to six carbon atoms; R4, R5, R6 and R7 are independently hydrogen, lower alkyl of one to six carbon atoms, alkoxy, acyl or halo; are advantageously converted to thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.