60573-88-8 Usage
Description
Ibotenic Acid Monohydrate is a white to off-white solid that is a hydrate of Ibotenic Acid and a conformationally restricted analog of glutamic acid. It functions as an excitatory amino acid receptor agonist and is a constituent of Amanita muscaria.
Uses
Used in Pharmaceutical Industry:
Ibotenic Acid Monohydrate is used as a pharmaceutical agent for its agonistic effects on excitatory amino acid receptors. Its ability to mimic the action of glutamic acid makes it a valuable compound in the development of drugs targeting neurological disorders and conditions related to neurotransmission.
Used in Research and Development:
In the field of research and development, Ibotenic Acid Monohydrate serves as a crucial tool for studying the mechanisms of excitatory neurotransmission and receptor function. Its use in laboratory settings helps scientists understand the complex interactions between neurotransmitters and their receptors, ultimately contributing to the advancement of neurological therapies.
Used in Toxicology Studies:
Due to its presence in Amanita muscaria, a toxic mushroom, Ibotenic Acid Monohydrate is also utilized in toxicology studies. Understanding its role in the toxic effects of the mushroom can provide insights into the development of antidotes or treatments for mushroom poisoning.
Used in Neurochemical Analysis:
Ibotenic Acid Monohydrate is employed as a reference compound in neurochemical analysis, allowing researchers to compare its properties and effects with other neurotransmitters and receptor agonists. This helps in the identification of potential therapeutic targets and the development of more effective drugs for various neurological conditions.
Biochem/physiol Actions
Ibotenic acid, a mushroom chemical neurotoxin, is used alone and together with factors such as β-amyloid(25-35) to induce neurotoxic lesions in the brain.
Check Digit Verification of cas no
The CAS Registry Mumber 60573-88-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,5,7 and 3 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 60573-88:
(7*6)+(6*0)+(5*5)+(4*7)+(3*3)+(2*8)+(1*8)=128
128 % 10 = 8
So 60573-88-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)/t4-/m1/s1
60573-88-8Relevant articles and documents
Excitatory Amino Acids. Improved Synthesis of Ibotenic Acid and X-Ray Analysis of an Unexpected Reaction Product, (RS)-N--3-oxobutyramide
Madsen, Ulf,Brehm, Lotte,Krogsgaard-Larsen, Povl
, p. 359 - 364 (2007/10/02)
A new synthesis of the excitotoxic natural product ibotenic acid (1) is described.Benzylation of 3-hydroxy-5-methylisoxazole (5) yielded 3-benzyloxy-5-methylisoxazole (7) and the isomeric isoxazol-3(2H)-one (6).While metallation of compound (7) by lithium
