6024-85-7 Usage
Description
TETRAHYDROPALMATINE HYDROCHLORIDE, also known as the hydrochloride salt of DL-Tetrahydropalmatine, is a compound derived from the Chinese herb corydalis. It is recognized for its pharmacological properties, particularly its ability to induce hypotension and bradycardia in rats through the antagonism of the striatal dopamine D2 receptor.
Uses
Used in Pharmaceutical Industry:
TETRAHYDROPALMATINE HYDROCHLORIDE is used as an active pharmaceutical ingredient for its hypotensive and bradycardic effects. It is particularly effective in antagonizing the striatal dopamine D2 receptor, making it a potential candidate for the development of medications targeting cardiovascular conditions.
Used in Research Applications:
In the field of scientific research, TETRAHYDROPALMATINE HYDROCHLORIDE serves as a valuable tool for studying the role of dopamine D2 receptors in cardiovascular regulation. Its ability to induce hypotension and bradycardia in rats makes it a useful compound for investigating the mechanisms underlying these physiological responses and for developing new therapeutic strategies for related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 6024-85-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,2 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6024-85:
(6*6)+(5*0)+(4*2)+(3*4)+(2*8)+(1*5)=77
77 % 10 = 7
So 6024-85-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H25NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,10-11,17H,7-9,12H2,1-4H3;1H
6024-85-7Relevant articles and documents
Bioactive isoquinoline alkaloids from Corydalis saxicola
Huang, Qiao-Qin,Bi, Jun-Long,Sun, Qian-Yun,Yang, Fu-Mei,Wang, Yue-Hu,Tang, Gui-Hua,Zhao, Fu-Wei,Wang, Huan,Xu, Jin-Jin,Kennelly, Edward J.,Long, Chun-Lin,Yin, Ge-Fen
experimental part, p. 65 - 70 (2012/06/18)
Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)-2,9-dihydroxyl-3,11-dimethoxy-1,10- dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1a, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC 50 values of less than 10M, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity.
