6018-19-5 Usage
Description
Sodium 4-aminosalicylate dihydrate, also known as PAS, is a synthetic antimicrobial agent derived from the salicylic acid family. It is a white crystalline solid that is soluble in water and exhibits weakly acidic properties. Its chemical structure allows it to interact with various biological molecules, making it a valuable compound in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Sodium 4-aminosalicylate dihydrate is used as an antibiotic for the treatment of tuberculosis. It functions by inhibiting the NF-κB pathway, which is crucial for the survival and replication of Mycobacterium tuberculosis, the causative agent of tuberculosis. Additionally, it exhibits free radical scavenging properties, which help in reducing oxidative stress and inflammation associated with the disease.
Furthermore, Sodium 4-aminosalicylate dihydrate is also used in the treatment of inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, due to its anti-inflammatory and immunomodulatory effects. Its ability to modulate the immune response and reduce inflammation makes it a valuable therapeutic agent in managing these conditions.
Purification Methods
Recrystallise it from water at room temperature (2mL/g) by adding acetone and cooling. [Beilstein 14 III 1436, 14 IV 1969.]
Check Digit Verification of cas no
The CAS Registry Mumber 6018-19-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,1 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6018-19:
(6*6)+(5*0)+(4*1)+(3*8)+(2*1)+(1*9)=75
75 % 10 = 5
So 6018-19-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H7NO3.Na.2H2O/c8-4-1-2-5(7(10)11)6(9)3-4;;;/h1-3,9H,8H2,(H,10,11);;2*1H2/q;+1;;/p-1