60037-52-7

Basic information

• Product Name: N⁶,O^3'-methyladenosine
• Synonyms: N⁶,O^3'-methyladenosine
• CAS NO: 60037-52-7
• Molecular Weight: 295.298
• Mol File: 60037-52-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N⁶,O^3'-methyladenosine(CAS DataBase Reference)
• NIST Chemistry Reference: N⁶,O^3'-methyladenosine(60037-52-7)
• EPA Substance Registry System: N⁶,O^3'-methyladenosine(60037-52-7)

Safety Data

• Hazardous Substances Data: 60037-52-7(Hazardous Substances Data)

Upstream product

• 17287-03-5 trimethylsulphonium hydroxide 
• 58-61-7 adenosine 
• 74230-06-1 trimethylselenonium hydroxyde 
• 10300-22-8 3'-O-methyladenosine 
• 1899-02-1 trimethylphenylammonium hydroxide 
• 512-56-1 trimethyl phosphite 

Relevant articles and documents

Selective 2'-O-Methylation of Pyrimidine-Ribonucleosides by Trimethylsulfonium Hydroxide in the Presence of Mg2+ and Ca2+ Ions

Reactions of various ribonucleosides with trimethylsulfonium hydroxide were investigated in the presence of Mg2+ and Ca2+ ions.The 2'-OH groups of pyrimidine-ribonucleosides were methylated selectively.

The Methylation of Ribonucleosides by Trimethyl Phosphate or Dimethyl Sulfate in the Presence of Boric Acid

Uridine, inosine, adenosine, and thymidine were methylated selectively at the base moieties by the use of trimethyl phosphate or dimethyl sulfate in the presence of boric acid.A suppressing effect of boric acid on the methylation of the ribose-hydroxyl groups was discussed briefly.

Methylation of Nucleosides with Trimethylsulfonium Hydroxide. Effects of Transition Metal Ions

The effect of transition metal acetylacetonates on the methylation of ribo- and deoxyribonucleosides with trimethylsulfonium hydroxide was studied.With ribonucleosides the metal complexes promoted O'-methylation at the 2' and 3' positions of the ribosyl group.A comparable effect was not observed in methylation of deoxyribonucleosides.These results are attributed to an increase in the nucleophilicity of the 2'-OH and 3'-OH groups of the ribosides through complex formation with the metal ion; such a complex cannot form with the deoxyribose derivatives.The activity of the metal ions studied for promoting this O'-methylation increased in the order Mn2+ 2+ = Zn2+ 2+ 2+ 3+.These M(AA)n also suppressed N-methylation of the purine and pyrimidine rings of adenosine and cytidine.It is suggested that this result may be caused by coordination of the metal ions with ring nitrogens.