59277-17-7

Basic information

• Product Name: Benzene, [(4-chloro-2-methyl-2-butenyl)sulfonyl]-, (E)-
• CAS NO: 59277-17-7
• Molecular Formula: C11H13ClO2S
• Molecular Weight: 244.742
• Mol File: 59277-17-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, [(4-chloro-2-methyl-2-butenyl)sulfonyl]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(4-chloro-2-methyl-2-butenyl)sulfonyl]-, (E)-(59277-17-7)
• EPA Substance Registry System: Benzene, [(4-chloro-2-methyl-2-butenyl)sulfonyl]-, (E)-(59277-17-7)

Safety Data

• Hazardous Substances Data: 59277-17-7(Hazardous Substances Data)

Upstream product

• 95684-41-6 1-chloro-4-phenylsulfinyl-3-methylbut-2E-ene 
• 4972-29-6 benzenesulphinyl chloride 
• 98-09-9 benzenesulfonyl chloride 
• 78-79-5 isoprene 

Downstream Products

• 73875-18-0 (2′E)-2-(3′-methyl-4′-phenylsulfonylbut-2′-enyl)-1,4-dimethoxy-3-methylnaphthalene 
• 2124-57-4 menaquinone-7 
• 1597486-93-5 2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-4-(phenylsulfonyl)octacosa-2,6,10,14,18,22,26-heptaen-1-yl)-1,4-dimethoxy-3-methylnaphthalene 
• 84-81-1 farnoquinone 
• 1597486-65-1 1,4-diethoxy-2-methyl-3-[(2E)-3-methyl-4-(phenylsulfonyl)-2-buten-1-yl]naphtalene 
• 73875-21-5 (2'E)-1-(3'-methyl-4'-phenylsulfonylbut-2'-enyl)-6-methyl-2,3,4,5-tetramethoxybenzene 
• 64634-91-9 1-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-3,4-dimethoxy-2,5-bis(methoxymethoxy)-6-methylbenzene 
• 74813-93-7 4-(benzenesulfonyl)-3,7,11,15,19,23,27,31,35,39-decamethyl-1-[3,4-dimethoxy-2,5-bis(methoxymethoxy)-6-methylphenyl]tetraconta-2,6,10,14,18,22,26,30,34,38-decaene 
• 73875-22-6 (E)-1-(benzenesulfonyl)-4-[3,4-dimethoxy-2,5-bis(methoxymethoxy)-6-methylphenyl]-2-methylbut-2-ene 
• 1092067-54-3 (E)-6-[4-(benzenesulfonyl)-3-methylbut-2-enyl]-2,3-dimethoxy-5-methylbenzene-1,4-diol 
• 303-98-0 ubidecarenone 

Relevant articles and documents

Convergent Synthesis of Menaquinone-7 (MK-7)

A practical synthesis of menaquinone-7 (MK-7, Vitamin K2) in the all-trans form was designed. Stereoselective synthesis of MK-7 was achieved through a "1 + 6" convergent strategy by condensation of two building blocks, menadione monoprenyl derivative (fragment "1") with hexaprenyl bromide (fragment "6", 82%). Pd-catalyzed desulfonation with LiEt3BH (78%) was followed by oxidation of the hydroquinone moiety using ammonium cerium(IV) nitrate (72%). The major challenge in our methodology was the preparation of all-trans hexaprenyl bromide by coupling of two triprenyl units derived from trans, trans-farnesol. Manufacturing on a pilot scale was accomplished through our approach. The scalable method was designed especially for a large, kilogram-scale production from easily available intermediates. Furthermore, the proposed methodology avoids many chromatographic purifications and allows for a relatively cost-effective manufacturing. Moreover, our synthesis yielded high-purity (99.9%) final product MK-7, which can be used as a dietary supplement as well as an active pharmaceutical ingredient.

LEWIS-ACID- OR HIGH-PRESSURE-INITIATED REGIO- AND STEREOSELECTIVE FUNCTIONALIZATION OF ISOPRENE UTILIZING PHENYLSULFINYL CHLORIDE

-

Sulphones with an alcohol group and their esters

Sulphones of the formula: where R is alkyl, aralkyl, alkylaryl or aryl, R1 is hydrogen or -COR2 where R2 is hydrogen, alkyl or aryl, and one of X and Y is methyl and the other is hydrogen are useful for converting terpene and carotenoid compounds into the immediately higher isoprenologue, useful as perfumes, foodstuff dyes, and pharmaceuticals.