592-17-6 Usage
Description
N-ISOBUTYLUREA, also known as Isobutyl Urea, is an organic compound with the chemical formula C5H11N2O. It is characterized by its white crystalline appearance and is primarily used in organic synthesis. Its unique chemical structure allows it to serve as a versatile building block for the creation of various chemical compounds and materials.
Uses
Used in Organic Synthesis:
N-ISOBUTYLUREA is used as a synthetic building block for the development of various chemical compounds. Its application in organic synthesis is due to its ability to react with other molecules, facilitating the formation of new compounds with diverse properties and potential applications.
Used in Pharmaceutical Industry:
N-ISOBUTYLUREA is used as an intermediate in the synthesis of pharmaceutical compounds. Its role in this industry is to provide a starting material or a key component for the development of new drugs, which can be used to treat a wide range of medical conditions.
Used in Chemical Research:
N-ISOBUTYLUREA is used as a research compound in the field of chemistry. Its application in chemical research is to study its properties, reactivity, and potential interactions with other molecules. This information can be valuable for understanding the underlying principles of chemical reactions and for designing new synthetic pathways.
Used in Material Science:
N-ISOBUTYLUREA is used as a component in the development of new materials. Its application in material science is to create novel materials with specific properties, such as improved strength, durability, or chemical resistance, which can be utilized in various industries, including automotive, aerospace, and electronics.
Synthesis Reference(s)
The Journal of Organic Chemistry, 16, p. 1879, 1951 DOI: 10.1021/jo50006a010
Check Digit Verification of cas no
The CAS Registry Mumber 592-17-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 2 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 592-17:
(5*5)+(4*9)+(3*2)+(2*1)+(1*7)=76
76 % 10 = 6
So 592-17-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H12N2O/c1-4(2)3-7-5(6)8/h4H,3H2,1-2H3,(H3,6,7,8)
592-17-6Relevant articles and documents
A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation
Christian, Alec H.,Jia, Shang,Cao, Wendy,Zhang, Patricia,Meza, Arismel Tena,Sigman, Matthew S.,Chang, Christopher J.,Toste, F. Dean
supporting information, p. 12657 - 12662 (2019/09/04)
We report a data-driven, physical organic approach to the development of new methionine-selective bioconjugation reagents with tunable adduct stabilities. Statistical modeling of structural features described by intrinsic physical organic parameters was applied to the development of a predictive model and to gain insight into features driving the stability of adducts formed from the chemoselective coupling of oxaziridine and methionine thioether partners through Redox Activated Chemical Tagging (ReACT). From these analyses, a correlation between sulfimide stabilities and sulfimide ν (C=O) stretching frequencies was revealed. We exploited the rational gains in adduct stability exposed by this analysis to achieve the design and synthesis of a bis-oxaziridine reagent for peptide stapling. Indeed, we observed that a macrocyclic peptide formed by ReACT stapling at methionine exhibited improved uptake into live cells compared to an unstapled congener, highlighting the potential utility of this unique chemical tool for thioether modification. This work provides a template for the broader use of data-driven approaches to bioconjugation chemistry and other chemical biology applications.
