58889-67-1

Basic information

• Product Name: NEUROTENSIN ACETATE SALT
• Synonyms: neurotensin acetate gamma-irradiated*cell culture;NEUROTENSIN ACETATE GAMMA-IRRADIATED*CEL L CULTURE T;NEUROTENSIN DIACETATE HEPTAHYDRATE, BO V INE;PGLU-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU ACETATE SALT;NEUROTENSIN ACETATE SALT;neurotensin acetate
• CAS NO: 58889-67-1
• Molecular Formula: C80H125N21O22
• Molecular Weight: 1732.98
• Product Categories: NeurotensinsProteomics;Mass Spectrometry;Neuropeptides;Peptide and protein standards for mass spectrometry analysis;Peptides for Cell Biology
• Mol File: 58889-67-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: NEUROTENSIN ACETATE SALT(CAS DataBase Reference)
• NIST Chemistry Reference: NEUROTENSIN ACETATE SALT(58889-67-1)
• EPA Substance Registry System: NEUROTENSIN ACETATE SALT(58889-67-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 58889-67-1(Hazardous Substances Data)

Usage

Description

Neurotensin Acetate Salt, also known as NT, is a tridecapeptide encoded by the gene located on human chromosome 12q21.31. It consists of a specific amino acid sequence and is widely distributed in the gastrointestinal tract and central nervous system, with high levels found in the hypothalamus, amygdala, and nucleus accumbens, as well as lower levels in peripheral blood.

Uses

Used in Pharmaceutical Industry:
Neurotensin Acetate Salt is used as a pharmaceutical compound for its potential therapeutic applications in various conditions. It is involved in the regulation of various physiological processes, including pain modulation, mood regulation, and gastrointestinal function.
Used in Analytical Chemistry:
Neurotensin Acetate Salt is used as an external calibration reagent for spectrum calibration, ensuring accurate and reliable results in analytical chemistry.
Used in Capillary Electrophoresis:
Neurotensin Acetate Salt is used to evaluate the performance of online capillary electrophoresis to matrix-assisted laser desorption ionization (CE-MALDI) systems, helping to improve the efficiency and effectiveness of these analytical techniques.

Biochem/physiol Actions

Neurotensin (NT) acts as an inducer for analgesia, hypothermia and hyperglycemia, and is an inhibitor of gastric motility. Plasma NT levels are high in children with Prader–Willi syndrome (PWS). NT secreted from small cell lung cancer cells might have a regulatory action in this disease. It has been implicated in regulation of gastric system and inflammatory processes in the lung. In addition, NT also regulates immune response by stimulating cytokine release and chemotaxis on interaction with leukocytes, peritoneal mast cells and dendritic cells. NT present in gastrointestinal (GI) tract plays a vital role in various processes such as stimulation of pancreatic and biliary secretion and enhances growth of various normal tissues. It is involved downstream of Wnt/β-catenin signaling pathway and stimulates the growth of neuroendocrine tumor cells.