58138-78-6Relevant articles and documents
An Unexpected Synthesis of a Dihydropyrrolo-[1,2-c]pyrimidinedione Nucleoside Analogue from 5-Fluorouracil
Grangier-McMath, Geraldine,Aitken, David J.,Guillaume, Dominique,Chiaroni, Angele,Riche, Claude,Husson, Henri-Philippe
, p. 260 - 261 (1998)
In the presence of an excess of LDA, the tandem deprotonation-alkylation reaction of 1-cyanomethyl-5-fluorouracil with epibromohydrin gives the novel dihydropyrrolo[1,2-c]pyrimidinedione 4 as a mixture of diastereoisomers.
Uracil analogues of the acylonucleoside 9--methyl>guanine (BIOLF-62)
Ogilvie, Kelvin K.,Hamilton, Raymond G.,Gillen, Michael F.,Radatus, Bruno K.,Smith, Kendall O.,Galloway, Karen S.
, p. 16 - 21 (2007/10/02)
A series of substituted uracil analogues of the antiviral agent 9-methyl>guanine (BIOL-62) has been synthesized and characterized.The uracil analogues show little activity against herpesviruses.
Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine
-
, (2008/06/13)
A process for producing bis-silyl derivatives of fluorinated pyrimidines is disclosed, wherein a 5-fluoro-6-hydroxy or alkoxy pyrimidine is reacted with a silane, such as triethylchlorosilane. The intermediate product produced by that reaction, which is obtained in high yield, may then be reacted with a further compound, which can be a blocked sugar halide or 2-chlorotetrahydrofuran, to produce a nucleoside of the pyrimidine. The nucleosides are useful as antibacterial and antiviral agents, and in the treatment of cancer.