58113-28-3

Basic information

• Product Name: N-acetyl-α,α-diphenyl-4-piperidinemethanol
• Synonyms: N-acetyl-α,α-diphenyl-4-piperidinemethanol
• CAS NO: 58113-28-3
• Molecular Weight: 309.408
• Mol File: 58113-28-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-acetyl-α,α-diphenyl-4-piperidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-α,α-diphenyl-4-piperidinemethanol(58113-28-3)
• EPA Substance Registry System: N-acetyl-α,α-diphenyl-4-piperidinemethanol(58113-28-3)

Safety Data

• Hazardous Substances Data: 58113-28-3(Hazardous Substances Data)

Upstream product

• 59084-16-1 1-acetylpiperidine-4-carbonyl chloride 
• 25503-90-6 1-acetyl-piperidine-4-carboxylic acid 
• 498-94-2 isonipecotic acid 
• 108-86-1 bromobenzene 
• 25519-79-3 1-(4-benzoylpiperidin-1-yl)ethanone 
• 108-90-7 chlorobenzene 

Downstream Products

• 50706-57-5 4-(diphenylmethylene)piperidine 
• 115-46-8 C₁₈H₂₁NO 

Relevant articles and documents

A α, α-diphenyl-4-piperidine methanol synthesis method

The invention discloses a method for synthesis of alpha,alpha-diphenyl-4-piperidine methanol. The method comprises the steps: taking 4-piperidine formic acid as a raw material, carrying out a reaction with an acetylation reagent to obtain N-acetyl piperidine formic acid; firstly generating N-acetyl piperidine formyl chloride from the obtained N-acetyl piperidine formic acid, and then carrying out a Friedel-Crafts acylation reaction with benzene to generate N-acetyl-4-benzoyl piperidine; carrying out a Grignard reaction of the obtained N-acetyl-4-benzoyl piperidine with phenyl magnesium halide to obtain N-acetyl-alpha,alpha-diphenyl-4-piperidine methanol; and deacetylating the N-acetyl-alpha,alpha-diphenyl-4-piperidine methanol to obtain the alpha,alpha-diphenyl-4-piperidine methanol. The synthesis method has the characteristics of cheap and easily obtained raw materials, simple process steps, high reaction yield and low costs of raw materials, and is suitable for industrialized production.