58-28-6 Usage
Description
Desipramine Hydrochloride is a tricyclic antidepressant medication that primarily functions as a potent inhibitor of the norepinephrine transporter, with a stronger effect on norepinephrine than on the serotonin transporter. It is used to treat various conditions by modulating the levels of neurotransmitters in the brain.
Uses
Used in Pharmaceutical Industry:
Desipramine Hydrochloride is used as a norepinephrine re-uptake inhibitor for the treatment of depression. It helps to increase the levels of norepinephrine in the brain, which contributes to an improvement in mood and reduction of depressive symptoms.
Used in Neuroprotection:
Desipramine Hydrochloride is used to prevent norepinephrine neuron degeneration and to maximize uptake into dopaminergic (DA) neurons. This helps protect the noradrenergic system from unselective damage, offering potential neuroprotective benefits.
Used in Preclinical Research:
Desipramine Hydrochloride is used in the treatment of rats for lesioning studies. As a tricyclic antidepressant, it serves as a more potent inhibitor of the norepinephrine transporter than the serotonin transporter, making it a valuable tool in research for understanding the mechanisms of action and potential therapeutic applications in various conditions.
Therapeutic Function
Psychostimulant
Biological Activity
Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
Biochem/physiol Actions
Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.
Safety Profile
Poison by ingestion,
intraperitoneal, subcutaneous, and
intravenous routes. Human systemic effects
by ingestion: decreased urine volume,
sodium level changes, chlorine level
changes. An experimental teratogen. Other
experimental reproductive effects. Mutation
data reported. When heated to
decomposition it emits very toxic fumes of
NO, and HCI.
Check Digit Verification of cas no
The CAS Registry Mumber 58-28-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 8 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 58-28:
(4*5)+(3*8)+(2*2)+(1*8)=56
56 % 10 = 6
So 58-28-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H