577978-91-7Relevant articles and documents
Diastereoselective synthesis of syn-aminoalcohols via contributing CH-π interaction: Simple synthesis of (-)-bestatin
Lee, Byong Won,Lee, Jin Hwan,Jang, Ki Chang,Kang, Jae Eun,Kim, Jin Hyo,Park, Ki-Min,Park, Ki Hun
, p. 5905 - 5907 (2007/10/03)
1H NMR and X-ray crystallography studies revealed that a CH-π and chelation control in aromatic aminoaldehydes (1-6) effects a highly diastereoselective addition to afford optically active syn-aminoalcohols (1a-6a). This methodology was applied to the synthesis of (-)-bestatin.