57521-85-4 Usage
Description
BOC-D-NVA-OH, also known as tert-Butyloxycarbonyl-D-Nva-OH, is a chemical compound with the molecular formula C10H19NO4S. It is a clear, colorless, viscid liquid that serves as a crucial reagent in the synthesis of various bioactive molecules. Its unique structure allows it to be used in the development of inhibitors and other pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
BOC-D-NVA-OH is used as a chemical reagent for the preparation of benzothiophene inhibitors of MK2, a protein kinase involved in various cellular processes, including inflammation and cancer. BOC-D-NVA-OH plays a vital role in the development of potential therapeutic agents targeting MK2, which could have significant implications in the treatment of various diseases.
Used in Cancer Research:
BOC-D-NVA-OH has been utilized in the synthesis of pyrrolidine diketopiperazines, a class of compounds that exhibit inhibitory effects on melanoma, a type of skin cancer. By incorporating this reagent into the synthesis process, researchers can develop novel inhibitors with potential applications in cancer treatment and prevention.
Check Digit Verification of cas no
The CAS Registry Mumber 57521-85-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,5,2 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 57521-85:
(7*5)+(6*7)+(5*5)+(4*2)+(3*1)+(2*8)+(1*5)=134
134 % 10 = 4
So 57521-85-4 is a valid CAS Registry Number.
57521-85-4Relevant articles and documents
NOVEL COMPOUNDS
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Page/Page column 45; 49; 50, (2020/01/11)
The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as modulators of alpha 1 antitrypsin and treating diseases associated with alpha antitrypsin, particularly liver diseases.
Synthesis of optically active β,γ-alkynylglycine derivatives
Meffre, Patrick,Gauzy, Laurence,Branquet, Eric,Durand, Philippe,Le Goffic, Francois
, p. 11215 - 11238 (2007/10/03)
Full results on the first synthesis of optically active β,γ-alkynylglycine derivatives from naturally occurring L-serine are described. The methodology uses L-serinal as a key intermediate and allows great versatility in the introduction of N-protective groups and of alkyne substitution. The N-Boc protected β,γ-alkynylglycine derivatives described have ee greater than 90%.
A short enantioselective synthesis of N-Boc-α-amino acids from epoxy alcohols
Poch, Marta
, p. 7781 - 7784 (2007/10/02)
A new and efficient enantioselective synthesis of Boc-α-amino acids has been developed. Starting from an enantiomerically enriched epoxy alcohol the sequence involves a regioselective nucleophilic epoxide opening by diphenylmethylamine (benzhydrilamine), hydrogenolysis/ protection of the amino group, and oxidation of the diol moiety.
