574749-29-4Relevant articles and documents
NOVEL APPROACH FOR SYNTHESIS OF CATECHINS
-
, (2016/01/15)
A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+and/or?) epicatechin echm and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (?)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.
Stereoselective substitution of flavan skeletons: Synthesis of dryopteric acid
Ohmori, Ken,Ushimaru, Naoko,Suzuki, Keisuke
, p. 7753 - 7756 (2007/10/03)
The C(4) acetoxylated catechin and epicatechin derivatives, 4 and 5, smoothly react with various nucleophiles under Lewis acidic conditions, giving C(4)-elaborated flavan-3-ols. Facile synthesis of dryopteric acid (3) was achieved.