57375-25-4

Basic information

• Product Name: 3-BroMorifaMycin S
• Synonyms: 3-BroMorifaMycin S
• CAS NO: 57375-25-4
• Molecular Formula: C₃₇H₄₄BrNO₁₂
• Molecular Weight: 774.6488
• Product Categories: Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 57375-25-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 937.3°C at 760 mmHg
• Flash Point: 520.6°C
• Appearance: /
• Density: 1.45g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: Amber Vial, -86°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Stability: Light Sensitive, Temperature Sensitive
• CAS DataBase Reference: 3-BroMorifaMycin S(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMorifaMycin S(57375-25-4)
• EPA Substance Registry System: 3-BroMorifaMycin S(57375-25-4)

Safety Data

• Hazardous Substances Data: 57375-25-4(Hazardous Substances Data)

Usage

Uses

3-Bromorifamycin S is a derivative of Rifamycin (R508200), an antibacterial agent.

InChI:InChI=1/C37H44BrNO12/c1-15-11-10-12-16(2)36(47)39-27-26(38)31(44)23-24(32(27)45)30(43)20(6)34-25(23)35(46)37(8,51-34)49-14-13-22(48-9)17(3)33(50-21(7)40)19(5)29(42)18(4)28(15)41/h10-15,17-19,22,28-29,33,41-43H,1-9H3,(H,39,47)/b11-10+,14-13+,16-12+

Upstream product

• 62623-68-1 rifamycin S 
• 6998-60-3 rifamycin SV 

Downstream Products

• 62041-01-4 3-amino-4-imino-rifamycin S 
• 123812-43-1 16,17,18,19,28,29-hexahydro-3-rifamycin SV 
• 123812-42-0 16,17,18,19-tetrahydro-3-rifamycin SV 
• 96165-99-0 C₄₉H₅₅N₃O₁₂ 
• 80621-81-4 rifaximin 
• 113102-19-5 2'-(N,N-diethylamino)rifamycin P 
• 109006-01-1 3-rifamycin SV 

Relevant articles and documents

Rifaximin hapten and rifaximin artificial antigen, and preparation methods and application thereof

The invention discloses a rifaximin hapten and a rifaximin artificial antigen, and a preparation method and application of the rifaximin hapten and the rifaximin artificial antigen. The rifaximin artificial antigen provided by the invention is an antigen obtained by coupling the rifaximin hapten shown as a formula I which is described in the specification with a carrier protein. The rifaximin artificial antigen provided by the invention is simple in synthesis method, high in purity and high in yield, and has important value for preparation of a rifaximin antibody and detection of rifaximin drug residues.

AN IMPROVED PROCESS FOR THE PREPARATION OF RIFAMYCIN DERIVATIVES

The present invention relates to an improved and industrially advantageous process for the preparation of Rifaximin with high purity and yield. Particularly, the present invention relates to improved processes for the preparation of Rifaximin from Rifamycin O and S. More particularly the present invention relates to a process for the preparation of Rifaximin through 3-halorifamycin S. The present invention further relates to a novel polymorph of Rifaximin and process for its preparation.

RIFAMYCIN DERIVATIVES EFFECTIVE AGAINST DRUG-RESISTANT MICROBES

Rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms are claimed in this invention. The inventive rifamycin derivatives are uniquely designed in that they have a rifamycin moiety covalently linked to a linker group through the C-3 carbon of the rifamycin moiety and the linker is, in turn covalently linked to a therapeutic moiety or antibacterial agent/pharmacophore. The therapeutic moiety can be a quinolone, an oxazolidinone, a macrolide, an aminoglycoside, a tetracycline core or a structure/pharmacophore associated with an antibacterial agent.