55627-73-1 Usage
Description
8-BROMOINOSINE is a white to yellow solid that is utilized in the synthetic preparation of various purine derivatives, including (bromo)adenosine and (bromo)guanosine. It plays a significant role in the development of compounds with potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
8-BROMOINOSINE is used as a synthetic precursor for the preparation of (bromo)adenosine and (bromo)guanosine derivatives. These derivatives are essential in the development of new drugs and therapies, particularly in the treatment of various diseases and conditions.
Used in Chemical Synthesis:
8-BROMOINOSINE is used as a reagent/reactant in the preparation of purine-substituted methylglucosamines. This application is crucial for the development of new compounds with potential immunostimulating activity, which can be beneficial in the field of medicine and healthcare.
Used in Microwave-Mediated Synthesis:
8-BROMOINOSINE is employed in microwave-mediated regioselective and chemoselective bromination of adenosine, inosine, and guanosine derivatives. This method allows for efficient and targeted synthesis of specific compounds, which can be advantageous in various research and development applications.
Check Digit Verification of cas no
The CAS Registry Mumber 55627-73-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,6,2 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55627-73:
(7*5)+(6*5)+(5*6)+(4*2)+(3*7)+(2*7)+(1*3)=141
141 % 10 = 1
So 55627-73-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H11BrN4O5/c11-10-14-4-7(12-2-13-8(4)19)15(10)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H,12,13,19)
55627-73-1Relevant articles and documents
The supramolecular helical architecture of 8-oxoinosine and 8-oxoguanosine derivatives
Lena, Stefano,Cremonini, Mauro A.,Federiconi, Francesco,Gottarelli, Giovanni,Graziano, Carla,Laghi, Luca,Mariani, Paolo,Masiero, Stefano,Pieraccini, Silvia,Spada, Gian Piero
, p. 3441 - 3449 (2008/02/07)
The 8-oxoguanosine derivative 1 and the 8-oxoinosine derivative 2b, with appropriate substituents on their ribose moieties, form hexagonal lyotropic mesophases in hydrocarbon solvents. Small-angle X-ray scattering analysis of a film of 1 and of the mesophase of 2b, and NMR and CD spectra of isotropic solutions of 2b, indicate that in both cases the supramolecular structures adopted are continuous helices formed by a hydrogen-bond network between the heterocyclic bases. Notably, while derivative 2b, which bears large substituents on its ribose moiety, undergoes self-assembly and mesophase formation, oxoinosine 2a, with only decanoyl groups on its ribose moiety, does not. This may be ascribed to the reduced amphiphilic properties of the latter and the absence of aromatic groups.
Anti-HCV nucleoside derivatives
-
, (2008/06/13)
The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.
