5560-59-8 Usage
Description
Alverine citrate is the citrate salt of alverine, which is a result of the reaction between equimolar amounts of alverine and citric acid. It is a white or almost white, crystalline powder that acts as an antispasmodic, directly affecting intestinal and uterine smooth muscle. Alverine citrate is utilized in the treatment of irritable bowel syndrome and has various pharmacological applications.
Uses
Used in Pharmaceutical Industry:
Alverine citrate is used as an adrenergic-β3 receptor agonist for its antispasmodic properties, helping to alleviate symptoms of irritable bowel syndrome.
Used in Antimicrobial Studies:
Alverine citrate is used in studies of synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans, potentially enhancing the effectiveness of treatments against these fungal infections.
Used in Gastrointestinal Applications:
Alverine citrate is used as an antispasmodic for the efficacy of combination with simethicone on abdominal pain associated with irritable bowel syndrome, providing relief from discomfort and pain.
Used in Metabolic Research:
Alverine citrate is used in nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis, contributing to the understanding of metabolic pathways and potential therapeutic targets.
Used in Signal Transduction Network Studies:
Alverine citrate is used to study drug effects from a signal transduction network perspective, aiding in the comprehension of how various signaling pathways interact and influence cellular responses.
Used in Cancer Research:
Alverine citrate is used to enhance the cytotoxic effect of proteasome inhibitor MG132, potentially contributing to the development of novel cancer treatments.
Used in Smooth Muscle Research:
Alverine citrate is used to study the mechanism of action on phasic smooth muscles, which can provide insights into the functioning of muscles and the development of treatments for related conditions.
Used in Anticholinergic Applications:
Alverine citrate is used as an anticholinergic agent, which can help in the management of various conditions by blocking the action of acetylcholine, a neurotransmitter involved in muscle contractions and other physiological processes.
Therapeutic Function
Anticholinergic, Spasmolytic
Check Digit Verification of cas no
The CAS Registry Mumber 5560-59-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,6 and 0 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5560-59:
(6*5)+(5*5)+(4*6)+(3*0)+(2*5)+(1*9)=98
98 % 10 = 8
So 5560-59-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
5560-59-8Relevant articles and documents
Method for reducing residues of N-ethyl-3-phenylpropylamine in alverine
-
Paragraph 0055; 0063-0068; 0085-0093, (2018/11/03)
The invention relates to a method for reducing residues of N-ethyl-3-phenylpropylamine in alverine, and belongs to an impurity removal method of compounds. The method comprises the following steps: dissolving an intermediate alverine crude product containing impurity N-ethyl-3-phenylpropylamine into a water-insoluble organic solvent, extracting an organic layer by using an aqueous solution with appropriate pH and discarding a water layer; drying and filtering the organic layer, decompressing and evaporating the solvent to dryness. According to the method disclosed by the invention, a clear, simple and reliable solution to the residues of the N-ethyl-3-phenylpropylamine in the intermediate alverine is provided for the first time, so that the subsequently produced crude drug citric acid alverine has higher quality and the residue amount does not exceed 0.15 percent. The method has the advantages of simplicity, feasibility, low cost, few wastes and suitability for industrial popularization.
A new method for the preparation of alverine citrate
-
Paragraph 0013; 0016; 0017, (2017/01/31)
The invention discloses a novel preparation method of alverine citrate, which comprises the following steps: reacting 3-phenylhalopropane and ethylamine hydrochloride used as initial raw materials in an alkaline system to generate diphenylpropyl ethylamine, and refining under the interaction between the organic layer and the citric acid to obtain the alverine citrate. The process route has the characteristics of accessible raw materials, fewer reaction steps, mild conditions, high yield and the like and is simple to operate, and thus, is an environment-friendly synthesis route which can easily implement industrialization.