547-32-0 Usage
Description
Sodium sulfadiazine is an anhydrous, white, colorless, crystalline powder that is soluble in water and slightly soluble in alcohol. Its water solutions are alkaline, with a pH of 9-10, and it has the ability to absorb carbon dioxide from the air, leading to the precipitation of sulfadiazine. It is a sulfonamide antibiotic that is used to treat various bacterial infections.
Uses
Used in Pharmaceutical Industry:
Sodium sulfadiazine is used as a reactant/reagent for the preparation and crystal structure of aminophenyl sulfonamide tetrahalides, hydrochloride, and hydrobromide cocrystals with iodine. This application is crucial in the development of new pharmaceutical compounds and their structural analysis.
Used in Medical Research:
Sodium sulfadiazine serves as an internal standard for the determination of sulfapyridine in biological samples using high-performance liquid chromatography (HPLC) technique. This application aids in the accurate measurement and analysis of sulfapyridine levels in biological samples, which is essential for medical research and drug development.
Used in Clinical Treatment:
Sodium sulfadiazine is administered as a 5% solution in sterile water intravenously for patients requiring an immediately high blood level of the sulfonamide. This application is particularly useful in treating severe bacterial infections that require rapid and effective treatment.
Chemical Properties:
Sodium sulfadiazine is a white to yellow crystalline powder with the following properties:
2. pH: Its water solutions are alkaline, with a pH of 9-10.
3. Carbon Dioxide Absorption: It can absorb carbon dioxide from the air, leading to the precipitation of sulfadiazine.
Check Digit Verification of cas no
The CAS Registry Mumber 547-32-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 547-32:
(5*5)+(4*4)+(3*7)+(2*3)+(1*2)=70
70 % 10 = 0
So 547-32-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2,(H,12,13,14);/q;+1
547-32-0Relevant articles and documents
Salt forms of sulfadiazine with alkali metal and organic cations
Campbell, Gemma,Fisher, Rebecca,Kennedy, Alan R.,King, Nathan L. C.,Spiteri, Rebecca
, p. 472 - 479 (2018/04/19)
The structures of four salt forms of sulfadiazine (SDH) with alkali metal cations are presented. Three contain the deprotonated SD anion (C10H9N4O2S). These are the discrete complex diaqua{4-[(pyrimidin-2-ylazan
Characterization of silver sulfadiazine and related compounds.
Sandmann,Nesbitt Jr.,Sandmann
, p. 948 - 951,949,950 (2007/10/04)
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