54494-34-7

Basic information

• Product Name: jolkinolide E
• Synonyms: jolkinolide E;Helioscopinolide G;(4aR,10aR,11aR,11bR)-2,3,4,4a,5,6,10a,11,11a,11b-Decahydro-4,4,8,11b-tetramethyl-phenanthro[3,2-b]furan-9(1H)-one
• CAS NO: 54494-34-7
• Molecular Formula: C20H28O2
• Molecular Weight: 300.43512
• Mol File: 54494-34-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 182.3 °C
• Boiling Point: 458.5±24.0 °C(Predicted)
• Appearance: /
• Density: 1.09±0.1 g/cm3(Predicted)
• CAS DataBase Reference: jolkinolide E(CAS DataBase Reference)
• NIST Chemistry Reference: jolkinolide E(54494-34-7)
• EPA Substance Registry System: jolkinolide E(54494-34-7)

Safety Data

• Hazardous Substances Data: 54494-34-7(Hazardous Substances Data)

Usage

Description

Jolkinolide E is a potent bioactive diterpenoid compound isolated from the roots of Euphorbia fischeriana Steud. It is known for its significant anti-inflammatory and anticancer properties, positioning it as a promising candidate for drug development.
Used in Pharmaceutical Industry:
Jolkinolide E is used as an anticancer agent for its ability to inhibit the growth of various cancer cell lines, such as breast, lung, and liver cancer cells. It functions by inducing apoptosis and interfering with cell cycle progression, thereby exhibiting potential therapeutic applications in cancer treatment.
Additionally, jolkinolide E is used as an anti-inflammatory agent due to its capacity to inhibit the production of pro-inflammatory cytokines and mediators, highlighting its potential in addressing inflammatory conditions.

Upstream product

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• 1006693-19-1 (3R,4aR,4bR,8aR)-3-Hydroxy-4b,8,8-trimethyl-4,4a,4b,5,6,7,8,8a,9,10-decahydro-3H-phenanthren-2-one 
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Relevant articles and documents

TOTAL SYNTHESIS OF (+/-)-JOLKINOLIDE A, B, AND E UTILIZING A NEW MILD ESTERIFICATION FOLLOWED BY INTRAMOLECULAR WITTIG-HORNER REACTION

Jolkinolide A, B, and E were efficiently synthesized from 9-methoxycarbonyl-4,4,10-trimethyl-Δ6-8-octalone 8 through Δ8(14)-podocalpen-13-one 12.A new synthetic method of γ-ylidenbutenolide consisting of mild esterification and the s