5414-21-1Relevant articles and documents
Synthetic Studies on d-Biotin, Part 6:1 An Expeditious and Enantiocontrolled Approach to the Total Synthesis of d-Biotin via a Polymer-Supported Chiral Oxazaborolidine-Catalyzed Reduction of meso-Cyclic Imide Strategy
Chen, Fen-Er,Yuan, Jian-Li,Dai, Hui-Fang,Kuang, Yun-Yan,Chu, Yong
, p. 2155 - 2160 (2007/10/03)
An efficient and highly enantioselective synthesis of d-biotin from the known cis-1,3-dibenzyl-2-imidazolidone-4,5-dicarboxylic acid (5) was accomplished in 48% overall yield. The key reactions in the sequence involve the catalytic enantioselective reduction of meso-cyclic imide 6 using polymer-supported chiral oxazoborolidine, derived from (S)-α,α -diphenylprolinol and polymer-bound sulfonyl chloride, and the installation of the C5 side chain at C4 in the thiolactone 9 via a Ni/C-catalyzed Fukuyama coupling reaction.
Cortamidine oxide, a novel disulfide metabolite from the New Zealand basidiomycete (mushroom) cortinarius species
Nicholas,Blunt,Munro
, p. 341 - 344 (2007/10/03)
Three disulfide metabolites were isolated from the fruiting bodies of the basidiomycete (mushroom) Cortinarius sp., collected in the Catlins, New Zealand. The structures of these compounds were determined as the unsymmetrical disulfide cortamidine oxide (1), 2,2′-dithiobis(pyridine N-oxide) (2), and the symmetrical disulfide 3. Both 1 and 2 showed significant antimicrobial activity and cytotoxicity. 2,2′-Dithiobis(pyridine N-oxide) (2) and the symmetrical disulfide 3 are assumed to be artifacts of the isolation procedure.
ALKYLATION OF ANIONS ON SOLID INORGANIC SUPPORTS: SYNTHESIS OF NITRILES, ESTERS, PHENOLIC ETHERS AND MONO-C-SUBSTITUTED ACETOACETIC ESTERS.
Bram, G.,Fillebeen-Khan, T.,Geraghty, N.
, p. 279 - 290 (2007/10/02)
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