5407-04-5Relevant articles and documents
Preparation method of N,N-dimethylaminochloropropane hydrochloride
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Paragraph 0028-0039, (2020/06/05)
The invention belongs to the technical field of drug intermediate synthesis, and in particular, relates to a preparation method of N,N-dimethylaminochloropropane hydrochloride. The preparation methodcomprises the steps: by taking chloropropene and dimethylamine as raw materials, carrying out aza-Michael addition under the action of a catalyst, separating and purifying to obtain an N,N-dimethylaminochloropropane solution after the reaction is finished, and carrying out acidification salifying reaction to obtain the N,N-dimethylaminochloropropane hydrochloride. The preparation method has the advantages of high reaction speed, high conversion rate, good selectivity, simple post-treatment and the like, the product purity is 99.0% or above, and the molar yield is 88% or above.
Side chain impacts on pH- and thermo-responsiveness of tertiary amine functionalized polypeptides
Xiao, Chunsheng,Cheng, Yilong,Zhang, Yu,Ding, Jianxun,He, Chaoliang,Zhuang, Xiuli,Chen, Xuesi
, p. 671 - 679 (2014/02/14)
The systemic investigation of the structural impacts of side chains on the pH- and thermo-responsiveness of tertiary amine functionalized poly(l-glutamate)s (TA-PGs) was carried out. The TA-PGs polymers were effectively synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition click reaction of azido tertiary amines with poly(γ-propargyl-l-glutamate) (PPLG). Turbimetric measurements were performed to characterize the pH- and temperature-induced phase transition of TA-PGs in aqueous solution, which suggested a structural dependence of the properties on the N-substituted groups and the "linkers" between 1,2,3-triazole ring and the tertiary amine groups in the side chains. In detail, the pH responsive properties of TA-PGs were basically determined by the hydrophobicity of the N-substituted groups in the side chains and the pH transition point (pHt) decreased as the increasing hydrophobicity of the N-substituted groups, while the temperature-responsiveness of TA-PGs were affected by either the N-substituted groups or the "linkers." TA-PGs with a moderate N-substituted amine group (e.g., DEA, PR, and PD) or a branched "linker" (e.g., iso-propylene and 2-methylpropylene group) were more likely to express the LCST-type phase transition tuned by pH variation. These structure-property relationships revealed in this study would help to develop the applications of TA-PGs in smart drug delivery systems. Copyright
NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS
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Paragraph 0248, (2013/07/19)
The invention provides novel ethylene derivatives represented by Formula I, which may be used as selective estrogen receptor modulators (SERMs) and useful in the prophylaxis and/or treatment of estrogen-dependent conditions or conditions.