53956-04-0 Usage
Description
Glycyrrhizic acid ammonium salt, also known as Ammonium Glycyrrhizinate, is a white to slightly yellow powder derived from the licorice root (Glycyrrhiza glabra or other species of glycyrrhiza). It is prepared from the water extract of licorice root by acid precipitation, followed by neutralization with dilute ammonia. The resulting product, Monoammonium glycyrrhizinate (C42H62O16NH45H2O), is obtained through solvent extraction and separation techniques. It is characterized by its slight licorice flavor, intense and rounded sweetness, and good solubility in water, glycerin, and propylene glycol.
Uses
1. Used in Pharmaceutical Industry:
Glycyrrhizic acid ammonium salt is used as a pharmaceutical excipient and is classified as Generally Recognized As Safe (GRAS). It serves as a sweetener in the pharmaceutical industry due to its intense sweetness.
2. Used in Flavoring and Sweetening:
Glycyrrhizic acid ammonium salt is used as a flavoring and sweetening agent in the food and beverage industry. It is suitable for use in beverages, desserts, confectionary products, soups, and dressings, thanks to its slight licorice flavor and intense sweetness.
3. Used in Synthesis of Polyion Complex Nanocarriers:
Glycyrrhizic acid ammonium salt is used in the synthesis of polyion complex nanocarriers, which may act as a template for the design of other negatively charged water-soluble drugs, particularly for anti-inflammatory drugs with which it is associated.
4. Used as a Sweetener in the Food Industry:
Glycyrrhizic acid ammonium salt is used as a sweetener in the food industry, providing a natural alternative to artificial sweeteners. Its good thermal stability and stability over a pH range of 3.5–9 make it suitable for various applications in the food and beverage sector.
Biochem/physiol Actions
Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral.
Anticancer Research
Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.
Safety Profile
Moderately toxic by
intravenous route. An experimental
teratogen. Experimental reproductive
effects. Mutation data reported. When
heated to decomposition it emits toxic
fumes of NH3.
Purification Methods
Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]
Check Digit Verification of cas no
The CAS Registry Mumber 53956-04-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,5 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 53956-04:
(7*5)+(6*3)+(5*9)+(4*5)+(3*6)+(2*0)+(1*4)=140
140 % 10 = 0
So 53956-04-0 is a valid CAS Registry Number.
InChI:InChI=1/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21?,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1
53956-04-0Relevant articles and documents
Clear liquid skin cosmetic compositions
-
, (2008/06/13)
Disclosed is a clear liquid skin cosmetic composition (e.g., a lotion) in which one or more oily substances (such as oil-soluble perfumes, hormones and the like) are solubilized in water with the aid of a solubilizing agent comprising an 18α-glycyrrhizin (18α-glycyrrhizic acid sodium salt, potassium salt or ammonium salt) that is a novel compound derived from a conventional glycyrrhizin (i.e., any form of 18β-glycyrrhizin extracted from licorice root) or a glycyrrhizin composition consisting of an 18α-glycyrrhizin and an 18β-glycyrrhizin. This skin cosmetic composition is not irritative to the skin as contrasted with skin cosmetic compositions prepared by using a synthetic surface-active agent as the solubilizing agent, and is not subject to gelation in a slightly acidic to acidic pH range as contrasted with skin cosmetic compositions prepared by using an 18β-glycyrrhizin alone as the solubilizing agent. Moreover, this skin cosmetic composition exerts a mild action on the skin without causing irritation thereto, gives an agreeable feeling, and has excellent fluidity, usability and storage stability.
