5338-65-8

Basic information

• Product Name: AI3-18274
• Synonyms: AI3-18274;4-Octanoylmorpholine;1-(Morpholino)-1-octanone;1-Octanone, 1-(morpholino)-;4-(1-Oxooctyl)morpholine;4-Caprylylmorpholine;Brn 0144084;Morpholine, 4-(1-oxooctyl)- (9ci)
• CAS NO: 5338-65-8
• Molecular Formula: C₁₂H₂₃NO₂
• Molecular Weight: 213.3165
• Mol File: 5338-65-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 342.8°Cat760mmHg
• Flash Point: 161.1°C
• Appearance: /
• Density: 0.974g/cm³
• Vapor Pressure: 7.36E-05mmHg at 25°C
• Refractive Index: 1.466
• CAS DataBase Reference: AI3-18274(CAS DataBase Reference)
• NIST Chemistry Reference: AI3-18274(5338-65-8)
• EPA Substance Registry System: AI3-18274(5338-65-8)

Safety Data

• Hazardous Substances Data: 5338-65-8(Hazardous Substances Data)

Usage

General Description

AI3-18274 is a chemical compound that has been identified as a potential inhibitor of the enzyme dihydropteroate synthase (DHPS), which is involved in the synthesis of folic acid in bacteria. Folic acid is essential for the production of DNA and RNA, and inhibiting DHPS can prevent the growth and reproduction of bacteria. AI3-18274 has been studied for its potential as an antibacterial agent, particularly against drug-resistant strains of bacteria. Research has shown that AI3-18274 has the ability to effectively inhibit DHPS and has the potential to be developed into a new class of antibiotics. Further research is needed to fully understand its mechanism of action and its potential as a therapeutic agent.

InChI:InChI=1/C12H23NO2/c1-2-3-4-5-6-7-12(14)13-8-10-15-11-9-13/h2-11H2,1H3

Upstream product

• 110-91-8 morpholine 
• 124-07-2 Octanoic acid 
• 111-87-5 octanol 
• 13125-66-1 n-heptylmagnesium bromide 
• 124-13-0 Octanal 
• 111-64-8 n-octanoic acid chloride 
• 58068-80-7 1-(n-octanoyl)benzotriazole 
• 6304-39-8 caprylic hydrazide 

Downstream Products

• 13063-60-0 N-1-octyl morpholine 

Relevant articles and documents

XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids

Amides were produced from carboxylic acids and amines by using XtalFluor-E as an activator. Even poorly reactive carboxylic acids can be transformed to amides. In addition, optically active amines and/or carboxylic acids were not epimerized/racemized during the process.

Leishmanicidal potential of N-substituted morpholine derivatives: Synthesis and structure-activity relationships

A series of N-substituted morpholines 2-20 was synthesised by reacting various acid chlorides and alkyl halides with morpholine (1). All of the synthesised compounds 2-20 were screened for their leishmanicidal effects using amphotericin B (IC50 = 0.24 μg L-1) and pentamidine (IC50 = 2.56 μg mL-1) as standards and a structure-activity relationship (SAR) study was established. The compounds 2 (IC50 = 48 μg mL-1), 3 (IC50 = 30.0 μg mL-1), 10 (IC50 = 41.0 μg mL-1), 15 (IC50 = 33.0 μg mL-1), 16 (IC50 = 35.0 μg mL-1) and 20 (IC50 = 47.0 μg mL-1) showed weak leishmanicidal activities.

Process for the preparation of carboxylic acid amides by oxidation of aldehydes in the presence of amines

Verfahren zur Herstellung von mono-, bi- oder/und polyfunktionellen Amiden der Formeln (Ia) oder/und (Ib),R1-CO-NR2R3R4R5N-CO-R6-CO- NR2R3aus Aldehyden und Aminen in Gegenwart eines übergangsmetallkatalysators und einem Oxidationsmittel.