53267-01-9 Usage
Description
Cibenzoline, also known by its brand name CIPRALAN, is a structurally novel class I antiarrhythmic agent that exhibits quinidine-like properties. It possesses additional characteristics of class III and class IV compounds, which include delaying repolarization and counteracting the positive inotropic effects of calcium. This makes Cibenzoline a versatile and effective pharmaceutical compound for managing various cardiac conditions.
Uses
Used in Pharmaceutical Industry:
Cibenzoline is used as a class I antiarrhythmic agent for treating cardiac arrhythmias. Its unique combination of class I, III, and IV properties allows it to effectively manage and regulate abnormal heart rhythms, providing a comprehensive approach to cardiac treatment.
Used in Cardiology:
As a cardiac depressant, Cibenzoline is utilized to reduce the force and rate of heart contractions. This application is particularly beneficial in managing conditions where the heart is overworking or experiencing excessive stress, such as in certain types of arrhythmias or heart failure.
Originator
Hexachemie (France)
Check Digit Verification of cas no
The CAS Registry Mumber 53267-01-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,2,6 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 53267-01:
(7*5)+(6*3)+(5*2)+(4*6)+(3*7)+(2*0)+(1*1)=109
109 % 10 = 9
So 53267-01-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H18N2/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17/h1-10,16H,11-13H2,(H,19,20)
53267-01-9Relevant articles and documents
NOVEL PROCESS FOR THE PREPARATION OF (+)-CIBENZOLINE SUCCINATE
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Paragraph 204-208, (2020/05/12)
The present invention relates to a crystalline form of (+)-Cibenzoline succinate. The present invention is also related to a process for the preparation of (+)-Cibenzoline succinate with chiral purity greater than 99.9%. The present invention also provides a process for the preparation of (+)-Cibenzoline succinate and a crystalline form thereof.
Novel process for the synthesis of class I antiarrhythmic agent (±)-cibenzoline and its analogs
Gholap, Atul R.,Paul, Vincent,Srinivasan, Kumar V.
, p. 2967 - 2982 (2008/12/22)
Synthesis of (±)-cibenzoline and its analogs has been achieved by a simple sequence of reactions. The diaryl cyanoolefin intermediate 3 could be prepared by Knoevenagel condensation of benzophenone with ethylcyanoacetate to form the tetra-substituted olefin intermediate 2 followed by Krapcho deethoxycarbonylation or from β-hydroxynitrile intermediate 2' followed by the elimination of hydroxyl group respectively. The 2,2- diphenylcyclopropanecarbonitrile 4 was synthesized from intermediate 3 by cyclopropanation, which was converted to (±)-2-(2,2-diphenylcyclopropyl)- 2-imidazoline 5 by reaction with ethylenediamine in the presence of a catalytic amount of sulfur. Moreover, the obtained 2-imidazolines were smoothly oxidized to the corresponding imidazoles 6 in good to moderate yields. Copyright Taylor & Francis Group, LLC.
