52950-37-5

Basic information

• Product Name: (S)-4-AMino-3-phenylbutanoic acid hydrochloride
• Synonyms: (S)-4-AMino-3-phenylbutanoic acid hydrochloride
• CAS NO: 52950-37-5
• Molecular Formula: C10H14ClNO2
• Molecular Weight: 215.67666
• Mol File: 52950-37-5.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (S)-4-AMino-3-phenylbutanoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-AMino-3-phenylbutanoic acid hydrochloride(52950-37-5)
• EPA Substance Registry System: (S)-4-AMino-3-phenylbutanoic acid hydrochloride(52950-37-5)

Safety Data

• Hazardous Substances Data: 52950-37-5(Hazardous Substances Data)

Usage

General Description

"(S)-4-Amino-3-phenylbutanoic acid hydrochloride" is a chemical compound that contains an amino group and a carboxylic acid group. It is a derivative of the naturally occurring amino acid phenylalanine, and is typically used as a pharmaceutical intermediate in the synthesis of various medications. (S)-4-AMino-3-phenylbutanoic acid hydrochloride has potential therapeutic uses, particularly in the treatment of anxiety and other neurological disorders. The hydrochloride salt form of this compound helps to increase its solubility in water, making it more suitable for use in medical applications. Overall, "(S)-4-Amino-3-phenylbutanoic acid hydrochloride" is an important chemical with medicinal potential.

Upstream product

• 1217022-86-0 (3S, 4R)-(-)-4-phenyl-3-carbethoxy-2-pyrrolidinone 
• 34687-03-1 4-nitro-3-phenylbutanoic acid methyl ester 
• 1431854-83-9 C₁₂H₁₇NO₂ 
• 78533-73-0 3-phenylglutaronitrile 
• 84872-79-7 4-amino-3-phenylbutanoic acid methyl ester 
• 62384-61-6 α-phenyl-β-benzoyl-γ-nitrobutyrate ethyl ester 
• 1198-97-6 4-phenylpyrrolidin-2-one 

Downstream Products

• 106869-48-1 4-phenyl-1-(trimethylsilyl)-2-pyrrolidinone 
• 71657-88-0 (4R)-4-phenyl-2-pyrrolidone 
• 68497-63-2 methyl-2-oxo-4-phenylpyrrolidine-1-acetate 
• 67118-34-7 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetic acid 
• 70291-40-6 2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester 
• 120438-10-0 C₁₅H₂₁NO₃Si 

Relevant articles and documents

Divergent Synthesis of γ-Amino Acid and γ-Lactam Derivatives from meso-Glutaric Anhydrides

The first divergent synthesis of both γ-amino acid and γ-lactam derivatives from meso-glutaric anhydrides is described. The organocatalytic desymmetrisation with TMSN3 relies on controlled generation of a nucleophilic ammonium azide species mediated by a polystyrene-bound base to promote efficient silylazidation. After Curtius rearrangement of the acyl azide intermediate to access the corresponding isocyanate, hydrolysis/alcoholysis provided uniformly high yields of γ-amino acids and their N-protected counterparts. The same intermediates were shown to undergo an unprecedented decarboxylation–cyclisation cascade in situ to provide synthetically useful yields of γ-lactam derivatives without using any further activating agents. Mechanistic insights invoke the intermediacy of an unconventional γ-N-carboxyanhydride (γ-NCA) in the latter process. Among the examples prepared using this transformation are 8 APIs/molecules of considerable medicinal interest.

Synthesis of Nonracemic Tetrazole GABA Analogs

Nonracemic 3-substituted 4-(1H-tetrazol-1-yl)butanoic acids, analogs of the neurotropic drugs phenibut, tolibut, and baclofen, were synthesized by a three-component reaction of the R-isomers of the corresponding amino acids, triethyl orthoformate, and sod

A novel method for the synthesis of racemic pregabalin, baclofen and 3-phenibut involving lossen rearrangement

Pregabalin,baclofen,and3-phenibutareγ-aminobutyricacid receptorsusedasanticonvulsant agents. The racemic forms of these anticonvulsants have been prepared by Lossen rearrangement. This procedure also provides an easy method to prepare carbamates useful intermediates to prepare anticonvulsants. This process is economical and easy to scale-up and yields are good.