52727-57-8 Usage
Description
Benzoic acid, 2-amino-5-bromo-, methyl ester, also known as Methyl 2-amino-5-bromobenzoate (M2A5B), is a white to light yellow crystal powder with unique chemical properties. It is characterized by its zigzag chains running along the b-axis direction, formed by N-H...O bonds. The nonlinear optical single crystal of M2A5B exhibits good optical transparency and mechanical stability, making it a promising candidate for various applications.
Uses
Used in Pharmaceutical Industry:
Benzoic acid, 2-amino-5-bromo-, methyl ester is used as a potential PqsD inhibitor for combating Pseudomonas aeruginosa infections. It plays a crucial role in inhibiting the growth and progression of this bacterial pathogen, providing a valuable therapeutic option in the fight against resistant infections.
Used in Antiviral Applications:
In the field of antiviral research, Benzoic acid, 2-amino-5-bromo-, methyl ester is utilized in the preparation of hepatitis C virus NS5b RNA polymerase inhibitors. These inhibitors are essential in the development of novel antiviral drugs, targeting the replication process of the hepatitis C virus and potentially leading to more effective treatments.
Used in Agriculture:
Benzoic acid, 2-amino-5-bromo-, methyl ester is involved in plant growth-regulator activity. It is used as a chemical agent to modulate and control plant growth, which can be beneficial in optimizing crop yields and improving overall agricultural productivity.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 7055, 1994 DOI: 10.1016/0040-4039(94)88224-X
Check Digit Verification of cas no
The CAS Registry Mumber 52727-57-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,2 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 52727-57:
(7*5)+(6*2)+(5*7)+(4*2)+(3*7)+(2*5)+(1*7)=128
128 % 10 = 8
So 52727-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H8BrNO2/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4H,10H2,1H3
52727-57-8Relevant articles and documents
A Practical Procedure for Regioselective Bromination of Anilines
Takahashi, Yusuke,Seki, Masahiko
, p. 1828 - 1832 (2021/04/15)
A highly practical procedure for the preparation of bromoanilines by using copper-catalyzed oxidative bromination has been developed. Treatment of free anilines with readily available NaBr and Na 2S 2O 8in the presence of a catalytic amount of CuSO 4·5H 2O enabled regioselective bromination.
METHOD FOR PRODUCING AROMATIC HALOGEN DERIVATIVE
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Paragraph 0127-0131, (2020/07/28)
PROBLEM TO BE SOLVED: To provide a highly efficient and economically advantageous method for producing a halogen compound. SOLUTION: The method produces a halogen compound represented by formula (2) (X is a halogen atom, and b is an integer of 1-5) by reacting an aniline derivative represented by formula (1) (R1 is an ester group, a carbonyl group, a nitrile group, a nitro group, an optionally substituted alkyl group or an optionally substituted aralkyl group, and a is an integer of 0-4) with a halogenating agent in the presence of a copper catalyst and a persulfate. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
Imidazo[1,5-a]quinazoline-5(4H)-ketone derivative as well as preparation method and application thereof
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Paragraph 0158-0163, (2020/08/22)
The invention relates to an imidazo[1,5-a]quinazoline-5(4H)-ketone derivative as well as a preparation method and application thereof. The imidazo[1,5-a]quinazoline-5(4H)-ketone derivative disclosed by the invention can be used for preparing a BET protein