52204-65-6Relevant articles and documents
INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION
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Paragraph 00994-00996, (2021/10/15)
Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.
Liquid-phase Hydrodeoxygenation of 4-Propylphenol to Propylbenzene: Reducible Supports for Pt Catalysts
González Escobedo, José Luis,Karinen, Reetta,Lahtinen, Jouko,Lassi, Ulla,Lindblad, Marina,M?kel?, Eveliina,Neuvonen, Jouni,Puurunen, Riikka L.
, (2020/07/06)
Pyrolysis and liquefaction biocrudes obtained from lignocellulose are rich in phenolic compounds that can be converted to renewable aromatics. In this study, Pt catalysts on reducible metal oxide supports (Nb2O5, TiO2), along with irreducible ZrO2 as a reference, were investigated in the liquid-phase hydrodeoxygenation (HDO) of 4-propylphenol (350 °C, 20 bar H2, organic solvent). The most active catalyst was Pt/Nb2O5, which led to the molar propylbenzene selectivity of 77 percent, and a yield of 75 percent (98 percent conversion). Reducible metal oxide supports provided an increased activity and selectivity to the aromatic product compared to ZrO2, and the obtained results are among the best reported in liquid-phase. The reusability of the spent catalysts was also studied. The spent Pt/Nb2O5 catalyst provided the lowest conversion, while the product distribution of the spent Pt/ZrO2 catalyst changed towards oxygenates. The results highlight the potential of pyrolysis or liquefaction biocrudes as a source of aromatic chemicals.
Low-Temperature Catalytic Hydrogenolysis of Guaiacol to Phenol over Al-Doped SBA-15 Supported Ni Catalysts
Wang, Qiuyue,Chen, Yufang,Yang, Guanheng,Deng, Ping,Lu, Xinqing,Ma, Rui,Fu, Yanghe,Zhu, Weidong
, p. 4930 - 4938 (2020/08/26)
Selective hydrogenolysis of aromatic carbon-oxygen (Caryl?O) bonds is a key strategy for the generation of aromatic chemicals from lignin. However, this process is usually operated at high temperatures and pressures over hydrogenation catalysts, resulting in a low selectivity for aromatics and an extra consumption of hydrogen. Here, a series of Al-doped SBA-15 mesoporous materials with different Si/Al molar ratios (Al-SBA-15) were prepared via a post-synthesis method using NaAlO2 as the Al source, and then Al-SBA-15 supported Ni catalysts (Ni/Al-SBA-15) were prepared by a deposition-precipitation method using urea as the hydrolysis reagent. The prepared supports and catalysts were extensively characterized using various techniques such as XRD, N2 adsorption/desorption, TEM, 27Al NMR, NH3-TPD, XPS, H2-TPR, and pyridine-FT-IR, and the catalysts were evaluated in the hydrogenolysis of the Caryl?O bond in guaiacol and lignin derived compounds under mild conditions. The effects of the Si/Al ratio in catalyst and reaction parameters on guaiacol conversion and product distribution were investigated in detail, associated with solvent effect. The incorporation of Al into the framework of SBA-15 can improve the Lewis acidity and the dispersion of the supported Ni particles and yet modulate the metal-support interactions, which are propitious to the hydrogenolysis of the Caryl?O bond in guaiacol. The catalyst Ni/Al-SBA-15 with a Si/Al molar ratio of 10 shows the best performance with a guaiacol conversion of 87.4 % and a phenol selectivity of 76.9 % under the mild conditions conducted, because of its proper acidity, suitable metal-support interactions, and high dispersion of the active species. The present study would stimulate research and development in multi-functional catalysts for the generation of valuable chemicals from biomass.
