521-35-7 Usage
Description
Cannabidiol, commonly known as CBD, is a naturally occurring compound found in the cannabis plant. It is a non-psychoactive substance, meaning it does not produce the "high" associated with marijuana use. CBD has gained significant attention for its potential therapeutic benefits and is known for its ability to act as a weak agonist of the CB1 and CB2 receptors in the body. It is typically found in the form of thin platelets and is derived from the metabolite of Tetrahydrocannabinol (THC).
Uses
Used in Pharmaceutical Industry:
Cannabidiol is used as a therapeutic agent for various medical conditions due to its potential anti-inflammatory, analgesic, and neuroprotective properties. It has shown promise in treating conditions such as epilepsy, anxiety, chronic pain, and neurodegenerative diseases like Alzheimer's and Parkinson's.
Used in Cosmetics Industry:
Cannabidiol is used as an ingredient in skincare products for its potential anti-inflammatory and antioxidant properties. It is believed to help with skin conditions like acne, eczema, and psoriasis by reducing inflammation and promoting skin health.
Used in Nutraceutical Industry:
Cannabidiol is used as a supplement in the form of oils, capsules, and edibles for its potential health benefits. It is believed to support overall well-being and may help with sleep, stress reduction, and general health maintenance.
Used in Veterinary Medicine:
Cannabidiol is used as a treatment option for pets, particularly for conditions like anxiety, arthritis, and epilepsy. It is believed to provide relief and improve the quality of life for animals suffering from these conditions.
Used in Drug Delivery Systems:
Cannabidiol can be incorporated into various drug delivery systems, such as transdermal patches, inhalers, and oral sprays, to improve its bioavailability and targeted delivery to specific areas of the body. This can enhance the therapeutic effects of CBD and minimize potential side effects.
Reactivity Profile
CANNABINOL is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Fire Hazard
Flash point data for CANNABINOL are not available, but CANNABINOL is probably combustible.
Biological Activity
CB 1 and CB 1 receptor agonist (K i values are 126 and 211 nM respectively). Inhibits adenylyl cyclase (EC 50 values are 120 and 261 nM for CB 1 and CB 2 receptors respectively) and suppresses immune cell function. Major constituent of cannabis; displays little or no psychotropic activity.
Purification Methods
Cannabinol crystallises from pet ether and sublimes in a vacuum. [Meitzer et al. Synthesis 985 1981, Beilstein 17 II 151, 17 III/IV 1652.]
Check Digit Verification of cas no
The CAS Registry Mumber 521-35-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 521-35:
(5*5)+(4*2)+(3*1)+(2*3)+(1*5)=47
47 % 10 = 7
So 521-35-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H26O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h9-13,22H,5-8H2,1-4H3
521-35-7Relevant articles and documents
Iodine-Promoted Aromatization of p -Menthane-Type Phytocannabinoids
Pollastro, Federica,Caprioglio, Diego,Marotta, Patrizia,Moriello, Aniello Schiano,De Petrocellis, Luciano,Taglialatela-Scafati, Orazio,Appendino, Giovanni
, p. 630 - 633 (2018)
Treatment with iodine cleanly converts various p-menthane-type phytocannabinoids and their carboxylated precursors into cannabinol (CBN, 1a). The reaction is superior to previously reported protocols in terms of simplicity and substrate range, which inclu
METHODS FOR SELECTIVE AROMATIZATION OF CANNABINOIDS
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Paragraph 0044-0049; 0053-0054; 0067-0069, (2022/02/11)
The present invention relates to methods of selective aromatization of cannabinoids. Such methods may be used, among other purposes, for the removal of delta-9-tetrahydrocannabinol from hemp extracts or other samples by selectively converting delta-9-tetrahydrocannabinol to cannabinol using ortho-quinone catalysts.
METHODS OF PREPARING SYNTHETIC CANNABINOL AND HOMOLOGS THEREOF
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Paragraph 0089; 00113; 00115-00116; 00120; 00122; 00124, (2021/02/05)
The present disclosure relates to the preparation of synthetic cannabinol and homologs thereof having the structure of Formula (I), wherein, n is 1, 2, 3 or 4. The methods described herein provide for high yields and purity in a one-pot synthesis or high yields and purity without the need for lengthy column chromatography. The present disclosure also relates to solid forms of cannabinol.
METHODS FOR CONVERTING TETRAHYDROCANNABINOLIC ACID INTO CANNABINOLIC ACID
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Paragraph 0049, (2021/03/05)
Disclosed herein is a method for converting tetrahydrocannabinolic acid (THCA) to cannabinolic acid (CBNA). The method comprises contacting an input material comprising THCA with a benzoquinone reagent under reaction conditions comprising: (i) a reaction temperature that is within a target reaction-temperature range; and (ii) a reaction time that is within a target reaction-time range, to provide an output material in which at least a portion of the THCA from the input material has been converted into CBNA.
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