52039-22-2

Basic information

• Product Name: Acetic acid, amino(diethoxyphosphinyl)-, phenylmethyl ester
• Synonyms: Acetic acid,amino(diethoxyphosphinyl)-,phenylmethyl ester
• CAS NO: 52039-22-2
• Molecular Formula: C13H20NO5P
• Molecular Weight: 301.279
• Mol File: 52039-22-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 405.9±40.0 °C(Predicted)
• Density: 1.209±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Acetic acid, amino(diethoxyphosphinyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, amino(diethoxyphosphinyl)-, phenylmethyl ester(52039-22-2)
• EPA Substance Registry System: Acetic acid, amino(diethoxyphosphinyl)-, phenylmethyl ester(52039-22-2)

Safety Data

• Hazardous Substances Data: 52039-22-2(Hazardous Substances Data)

Upstream product

• 55601-40-6 N-(benzyloxycarbonyl)aminomethylphosphonic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 142980-14-1 (+/-) benzyl N-t-BOC-2-bromoglycinate 
• 100-39-0 benzyl bromide 
• 54244-69-8 tert-butoxycarbonylamino-acetic acid benzyl ester 
• 142980-15-2 benzyl 2-(tert-butyloxycarbonylamino)-2-(diethyloxyphosphoryl)acetate 
• 7396-44-3 benzyl diethylphosphonoacetate 
• 52736-90-0 (Diethoxy-phosphoryl)-{[1-phenyl-meth-(E)-ylidene]-amino}-acetic acid benzyl ester 

Downstream Products

• 142979-99-5 [3-(2-Acetoxymethyl-[1,3]dioxolan-2-yl)-prop-(E)-ylideneamino]-(diethoxy-phosphoryl)-acetic acid benzyl ester 
• 143006-17-1 ((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-(diethoxy-phosphoryl)-acetic acid benzyl ester 
• 142980-01-6 2-[(2R,3S)-2-[2-(2-Acetoxymethyl-[1,3]dioxolan-2-yl)-ethyl]-3-((S)-2,2-dimethyl-4-phenyl-oxazolidin-3-yl)-4-oxo-azetidin-1-yl]-acrylic acid benzyl ester 
• 143006-18-2 (Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester 
• 143006-19-3 2-((2aR,7S,7bS)-4a-Acetoxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acrylic acid benzyl ester 
• 88088-34-0 [2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-pent-4-en-(Z)-ylideneamino]-(diethoxy-phosphoryl)-acetic acid benzyl ester 

Relevant articles and documents

Heterocyclic amides

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Preparation of Amino(diethoxyphosphoryl)acetic Esters. Catalytic Hydrogenation of Diazo Compounds to Amines

tert-Butyl amino(diethoxyphosphoryl)acetate (2a) is prepared on a multigram scale from tert-butyl diethoxyphosphorylacetate (1a) in a facile two-step synthesis.The method involves the formation of diazo derivative 4 and subsequent catalytic hydrogenation.Compound 2a is also synthesized by reduction of the oxime derivative 3.Direct amination of diethoxyphosphorylacetic esters with chloramine gives other types of esters 2b-e in addition to the tert-butyl ester 2a.

Total synthesis of β lactam antibiotics I. α Thioformamido diethylphosphonoacetates

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