52036-16-5 Usage
Description
(5Z)-5-(4-hydroxy-3-methoxybenzylidene)imidazolidine-2,4-dione is an imidazolidine-2,4-dione derivative characterized by a molecular formula of C11H11N3O4. (5Z)-5-(4-hydroxy-3-methoxybenzylidene)imidazolidine-2,4-dione features a benzylidene substituent and a hydroxy and methoxy group attached to the benzene ring, which contribute to its unique chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
(5Z)-5-(4-hydroxy-3-methoxybenzylidene)imidazolidine-2,4-dione is used as a potential inhibitor for the enzyme aldose reductase, which is implicated in diabetic complications. Its ability to inhibit this enzyme may lead to the development of new treatments for managing and preventing the progression of diabetes-related issues.
Used in Antioxidant Applications:
(5Z)-5-(4-hydroxy-3-methoxybenzylidene)imidazolidine-2,4-dione is used as an antioxidant agent due to its demonstrated antioxidant properties. Antioxidants are essential in neutralizing harmful free radicals, which can cause cellular damage and contribute to various diseases, including cancer and neurodegenerative disorders.
Used in Anti-inflammatory Applications:
(5Z)-5-(4-hydroxy-3-methoxybenzylidene)imidazolidine-2,4-dione is also used as an anti-inflammatory agent, as it has shown anti-inflammatory properties in some studies. Anti-inflammatory agents are crucial in the treatment of various conditions, such as arthritis, allergies, and other inflammatory diseases, where reducing inflammation can alleviate symptoms and promote healing.
Further research on (5Z)-5-(4-hydroxy-3-methoxybenzylidene)imidazolidine-2,4-dione may provide additional insights into its potential therapeutic applications, expanding its use in the pharmaceutical and healthcare industries.
Check Digit Verification of cas no
The CAS Registry Mumber 52036-16-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,3 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52036-16:
(7*5)+(6*2)+(5*0)+(4*3)+(3*6)+(2*1)+(1*6)=85
85 % 10 = 5
So 52036-16-5 is a valid CAS Registry Number.
52036-16-5Relevant articles and documents
Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents
Wen, Jiachen,Bao, Yu,Niu, Qun,Liu, Jiang,Yang, Jinyu,Wang, Wanqiao,Jiang, Tao,Fan, Yinbo,Li, Kun,Wang, Jian,Zhao, Linxiang,Liu, Dan
supporting information, p. 4372 - 4376 (2016/08/18)
In this study, a concise synthetic method of psammaplin A was achieved from 3-bromo-4-hydroxybenzaldahyde and hydantoin through a four-step synthesis via Knoevenagel condensation, hydrolysis, oximation and amidation in 37% overall yield. A collection of novel psammaplin A analogs focused on the variations of substituents at the benzene ring and modifications at the oxime moiety were synthesized. Among all the synthesized compounds, 5d and 5e showed better HDAC inhibition than psammaplin A and comparable cytotoxicity against four cancer cell lines (PC-3, MCF-7, A549 and HL-60). Molecular docking and dynamics simulation revealed that (i) hydrogen atom of the oxime group interacts with Asp99 of HDAC1 through a water bridged hydrogen bond and (ii) a hydroxyl group is optimal attached on the para-position of benzene, interacting with Glu203 at the entrance to the active site tunnel.
