52-88-0 Usage
Description
Atropine Methyl Nitrate is a synthetic quaternary ammonium compound derived from atropine, an alkaloid found in the deadly nightshade plant. It is a potent muscarinic antagonist with various applications in the medical and pharmaceutical industries. Atropine Methyl Nitrate is characterized by its melting point of 162-164°C and is available under the brand names Ekomine (Hoechst-Roussel) and Eumydrin (Sterling Winthrop).
Uses
Used in Pharmaceutical Industry:
Atropine Methyl Nitrate is used as an antimuscarinic agent for its ability to block the action of acetylcholine on muscarinic receptors, leading to a reduction in mucus production and respiratory secretions. This property makes it useful in the treatment of conditions characterized by excessive secretions, such as in rats.
Used in Antimicrobial Applications:
Atropine Methyl Nitrate is used as an antibacterial agent, demonstrating its effectiveness in inhibiting the growth of certain bacteria. This application highlights its potential use in the development of new antimicrobial drugs.
Used in Cephalosporin Antimicrobial Research:
Atropine Methyl Nitrate has been utilized in the study of its effects on xanomeline-induced suppression of serum tumor necrosis factor. This research contributes to the understanding of the compound's role in modulating immune responses and its potential use in the development of cephalosporin antimicrobials.
Originator
Methylatropine,Paganfarma
Manufacturing Process
There are 2 methods of synthesis of methyl atropine nitrate:
1) To a solution of 28.9 g atropine of in 100 g of methanol was added at
110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methyl
atropine nitrate was crystallysed, M.P. 163°C.
2) To a solution of 70.4 g methyl atropine sulfate (prepared from methyl
atropine chloride and silver nitrate) in water was added aqueous solution of
26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate was
concentrated and the methyl atropine nitrate was obtained.
Therapeutic Function
Anticholinergic, Mydriatic, Spasmolytic
Biochem/physiol Actions
Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.
Safety Profile
Poison by
intraperitoneal, intravenous, and
subcutaneous routes. Moderately toxic by
ingestion. Human systemic effects:
mydriasis. Experimental reproductive
effects. When heated to decomposition it
emits toxic fumes of NOx. See also
ATROPINE and NITRATES.
Check Digit Verification of cas no
The CAS Registry Mumber 52-88-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 52-88:
(4*5)+(3*2)+(2*8)+(1*8)=50
50 % 10 = 0
So 52-88-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H26NO3.NO3/c1-19(2)14-8-9-15(19)11-16(10-14)22-18(21)17(12-20)13-6-4-3-5-7-13;2-1(3)4/h3-7,14-17,20H,8-12H2,1-2H3;/q+1;-1/t14-,15+,16+,17?;
