51785-82-1

Basic information

• Product Name: BOC-PRO-GLY-OH
• Synonyms: BOC-PRO-GLY-OH;1-Boc-L-prolyl-glycine
• CAS NO: 51785-82-1
• Molecular Formula: C₁₂H₂₀N₂O₅
• Molecular Weight: 272.3
• Mol File: 51785-82-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 70 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 496.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.248±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.67±0.10(Predicted)
• CAS DataBase Reference: BOC-PRO-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-PRO-GLY-OH(51785-82-1)
• EPA Substance Registry System: BOC-PRO-GLY-OH(51785-82-1)

Safety Data

• Hazardous Substances Data: 51785-82-1(Hazardous Substances Data)

Usage

Description

BOC-PRO-GLY-OH is a dipeptide compound in the field of organic chemistry, consisting of the amino acids proline and glycine with a BOC (tert-butoxycarbonyl) protecting group attached. This BOC group shields the amine group of amino acids, preventing unwanted reactions during peptide synthesis. It serves as a fundamental building block for the creation of more complex peptides and as a reference compound for analytical purposes, playing a significant role in pharmaceutical development and the study of protein structure and function.

Uses

Used in Pharmaceutical Development:
BOC-PRO-GLY-OH is used as a building block for the synthesis of complex peptides, which are essential in the development of new pharmaceuticals. Its role in creating specific peptide sequences allows for the exploration of potential therapeutic agents and drug candidates.
Used in Protein Structure and Function Studies:
In the study of protein structure and function, BOC-PRO-GLY-OH is used as a reference compound. Its well-defined structure and properties make it a valuable tool for understanding the behavior of amino acids within peptides and proteins, contributing to the advancement of protein science.
Used in Organic Chemistry Research:
BOC-PRO-GLY-OH is utilized in organic chemistry research as a model compound for studying peptide synthesis and the effects of protecting groups on reaction outcomes. This helps researchers optimize synthetic routes and develop new methodologies for peptide chemistry.

Upstream product

• 57294-31-2 Boc-Pro-Gly-OEt 
• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 34290-72-7 tert-butyloxycarbonyl-prolyl-glycine methyl ester 
• 56-40-6 glycine 
• 57294-31-2 tert-butyl (S)-2-((2-ethoxy-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 147-85-3 L-proline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 109-02-4 4-methyl-morpholine 
• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 543-27-1 isobutyl chloroformate 
• 3392-10-7 Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(2,5-dioxo-pyrrolidin-1-yl) ester 
• 31953-80-7 N-tert-butyloxycarbonyl-(2S)-prolyl-glycine benzyl ester 
• 4530-20-5 BOC-glycine 

Downstream Products

• 92837-95-1 Boc-Pro-Gly-Cys(SBz)-NHMe 
• 2578-57-6 N-prolylglycine 
• 92411-00-2 Boc-Pro-Gly-Pro-OBzl 
• 7561-51-5 Pro-Gly-Pro 
• 123541-52-6 Cyclo(D-Phe-Pro-Gly-ProΨGly) 
• 123541-64-0 HCl*D-Phe-Pro-Gly-ProΨGly-OH 
• 123541-62-8 Boc-D-Phe-Pro-Gly-ProΨGly-OEt 
• 123541-63-9 Boc-D-Phe-Pro-Gly-ProΨGly-OH 
• 34290-72-7 tert-butyloxycarbonyl-prolyl-glycine methyl ester 

Relevant articles and documents

Leonurine derivative and application thereof in preparing medicine for preventing or treating ischemic cerebrovascular diseases

The invention provides a leonurine derivative and application of the leonurine derivative in preparation of a medicine for preventing or treating ischemic cerebrovascular diseases. The leonurine derivative has a structure as shown in a general formula (I), wherein X is selected from O or NH; Y is selected from any one of natural amino acid, substituted amino acid or amino alcohol; Z is selected from H, proline and any substituted proline. Pharmacological experiments prove that the leonurine derivative provided by the invention has the effects of neuroprotection, cerebral infarction area reduction and animal neurobehavioral scoring, and is good in safety, so that the leonurine derivative has important significance for developing novel medicines for preventing or treating ischemic cerebrovascular diseases.

METHOD FOR PRODUCING RECOMBINANT PEPTIDE AND RESULTANT PEPTIDE

PROBLEM TO BE SOLVED: To provide peptides with reproductive- and sexual-function stimulating activity. SOLUTION: The peptides are represented by general formula: A-Thr-Lys-Pro-B-C-D-X (where A is 0, Met, Met(O), Thr, Ala, His, Phe, Lys, or Gly; B is 0, Gly, Asp, Trp, Gln, Asn, Tyr, Pro, or Arg; C is 0, Arg, Phe, Tyr, Gly, His, Pro, or Lys; D is 0, Val, Gly, Tyr, Trp, Phe, or His; and X is OH, OCH3, or NH2; where 0 represents absence of the amino acid residue; provided that if A≠0 then B ≠0 and/or C≠0 and/or D≠0, if B≠0 then C≠0 and/or D≠0, and peptides Phe-Thr-Lys-Pro-Gly, Thr-Lys-Pro-Pro-Arg and Thr-Lys-Pro-Arg-Gly are excluded). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPO&INPIT

Synthesis of cytotoxic cyanobactin, Wewakazole B

We report herein the synthesis of cytotoxic cyanobactin, Wewakazole B through an efficient solution-phase approach. The key steps of the synthesis are the macrocyclic lactamization of linear dodecapeptide and construction of two hexapeptides with three di