51673-84-8Relevant articles and documents
Preparation method of 2, 2-dimethoxyacetaldehyde
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Paragraph 0026; 0028; 0029; 0031; 0032; 0034; 0035; 0037, (2020/07/21)
The invention discloses a preparation method of 1, 2-dimethoxyacetaldehyde. Hydroxyacetaldehyde is adopted as a raw material and a methanol raw material, S2O8 /Zn-MCM-41 solid superacid is adopted as a catalyst, the acidity is high and 2, 2-methoxyethanol can be obtained with high selectivity, then 2, 2-methoxyacetaldehyde is obtained under the action of an oxidizing agent, the product is easy to separate, and the purity of dimethoxyacetaldehyde reaches up to 95% or above.
A atorvastatin sandbank calcium chiral synthesis of intermediates method
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Paragraph 0034-0036, (2017/08/24)
The invention discloses a synthesis method for a chiral intermediate of atorvastatin calcium, and belongs to the technical field of medical intermediate synthesis. The synthesis method is characterized in that according to the process route, not only are dangerous, highly toxic and expensive chemicals such as butyl lithium, editpotassium cyanide and periodic acid in chemical synthesis prevented from being used, but also an ee value of the chiral intermediate is effectively improved due to usage of a mixed chiral catalysts of titanium iso-propylate and S-xenol. According to the synthesis method, the raw materials are low in cost and easy to obtain, the route operation is easy, the repeatability is good, the yield is very high, and the synthesis method is suitable for industrial production.
Fructose-6-phosphate aldolases as versatile biocatalysts for nitrocyclitol syntheses
Camps Bres, Flora,Guerard-Helaine, Christine,Fernandes, Carlos,Castillo, Jose A.,Lemaire, Marielle
, p. 1175 - 1181 (2013/10/08)
Efficient and stereoselective polyhydroxylated nitrocyclitol syntheses were performed via biocatalysed aldol reactions. The key step was based on a one-pot/one-enzyme cascade reaction process where two reactions occur: aldolase-catalysed aldolisation and spontaneous intramolecular nitroaldolisation. The synthetic methodology was investigated using fructose-6-phosphate aldolase A129S for the synthesis of known nitrocyclitols. Improvements were obtained which involved less steps and increased yields. Several new nitrocyclitols were also prepared using hydroxyacetone (HA) as the donor and FSA wt. From nitrocyclitol stereochemical analyses, the intramolecular nitro-Henry reaction stereoselectivity was dependent on the donor substrate used, HA or dihydroxyacetone (DHA). Whereas DHA provided two stereoisomers, four were obtained using HA.