51229-51-7

Basic information

• Product Name: 1-(4-(Bromomethyl)phenyl)ethanone
• Synonyms: 1-(4-(Bromomethyl)phenyl)ethanone;4'-BROMOMETHYLACETOPHENONE;Ethanone, 1-[4-(broMoMethyl)phenyl]-;1-[4-(broMoMethyl)phenyl]ethan-1-one;p-(Bromomethyl)acetophenone;p-Acetylbenzyl bromide;1-(4-(Bromomethyl)
• CAS NO: 51229-51-7
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.073
• Mol File: 51229-51-7.mol
• Article Data: 48

Chemical Properties

• Melting Point: 38.5-40.0℃
• Boiling Point: 134-136℃ (5 Torr)
• Flash Point: 94.1 °C
• Appearance: /
• Density: 1.416 g/cm³
• Vapor Pressure: 0.00195mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1-(4-(Bromomethyl)phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(Bromomethyl)phenyl)ethanone(51229-51-7)
• EPA Substance Registry System: 1-(4-(Bromomethyl)phenyl)ethanone(51229-51-7)

Safety Data

• Hazardous Substances Data: 51229-51-7(Hazardous Substances Data)

Usage

Description

1-(4-(Bromomethyl)phenyl)ethanone is an organic compound that features a bromomethyl group attached to a phenyl ring, which is connected to an ethanone group. This chemical structure endows it with specific reactivity and properties that make it valuable in various synthetic applications.

Uses

1. Used in Pharmaceutical Synthesis:
1-(4-(Bromomethyl)phenyl)ethanone is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly for the creation of dihydropyrimidine and thiopyrimidine derivatives. These derivatives have demonstrated antiviral properties, making them important in the development of new antiviral agents to combat viral infections.
2. Used in Chemical Research:
In the field of chemical research, 1-(4-(Bromomethyl)phenyl)ethanone serves as a versatile building block for the synthesis of a wide range of organic molecules. Its unique structure allows for further functionalization and modification, which can lead to the discovery of new compounds with potential applications in various industries.
3. Used in Material Science:
1-(4-(Bromomethyl)phenyl)ethanone may also find applications in material science, where its specific chemical properties could be exploited to develop new materials with tailored characteristics. For instance, its reactivity with other molecules could be utilized in the creation of novel polymers or coatings with specific properties.

InChI:InChI=1/C9H9BrO/c1-7(11)9-4-2-8(6-10)3-5-9/h2-5H,6H2,1H3

Upstream product

• 75633-63-5 4-(hydroxymethyl)acetophenone 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 122-00-9 para-methylacetophenone 
• 622-96-8 4-methylethylbenzene 
• 108-88-3 toluene 

Downstream Products

• 152595-77-2 1-[4-(3-Hydroxy-5-trifluoromethyl-1H-pyrazol-4-ylmethyl)-phenyl]-ethanone 
• 1237521-90-2 2-(4-acetylbenzylthio)-6-benzyl-5-ethylpyrimidin-4(3H)-one 
• 95827-11-5 4’-(acetoxymethyl)acetophenone 
• 1002299-74-2 3-(4-azidomethylphenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol 
• 1002299-79-7 3-(4-aminomethylphenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol 
• 1002299-72-0 1-(4-azidomethyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione 

Relevant articles and documents

Design, synthesis, biological activity evaluation of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole derivatives as potent JAK 2/3 and aurora A/B kinases multi-targeted inhibitors

In this study, a series of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole derivatives were designed, synthesized, and evaluated for their biological activities. Upon performing kinase assays, most of the compounds exhibited potent inhibition against JAK2/3 and Aurora A/B with the IC50 values ranging from 0.008 to 2.52 μM. Among these derivatives, compound 10e expressed the most moderate inhibiting activities against all the four kinases with the IC50 values of 0.166 μM (JAK2), 0.057 μM (JAK3), 0.939 μM (Aurora A), and 0.583 μM (Aurora B), respectively. Moreover, most of the derived compounds exhibited potent cytotoxicity against human chronic myeloid leukemia cells K562 and human colon cancer cells HCT116, while compound 10e expressed antiproliferative activities against K562 (IC50=6.726 μM). According to western blot analysis, compound 10e down-regulated the phosphorylation of STAT3, STAT5, Aurora A, and Aurora B in a dose-dependent manner in K562 and HCT116 cells. Cell cycle analysis revealed that compound 10e inhibited the proliferation of cells by inducing cell cycle arrest in the G2 phase. The molecular modeling suggested that compound 10e could maintain a binding mode similar to the binding mode of AT9832, a common JAK 2/3 and Aurora A/B kinases multi-target kinase inhibitor. Therefore, compound 10e might be a potential agent for cancer therapy deserving further research.

Non-natural amino acid and application thereof Recombinant protein and recombinant protein conjugate comprising same

The invention provides a non-natural amino acid. A compound represented by formula (I) or an enantiomer thereof. The invention also provides application of the non-natural amino acid. Further, the present invention also provides a protein conjugate comprising the recombinant protein and of the non-natural amino acid prepared from the recombinant protein. The non-natural amino acid provided by the invention is simple and convenient to prepare, good in safety, not prone to inactivation during protein insertion, high in conjugate rate with a coupling part, and higher in stability of the obtained conjugate.

3-(4-phenyl-1H-2-imidazolyl)-1H-pyrazole compound as well as preparation method and application thereof

The invention relates to a 3-(4-phenyl-1H-2-imidazolyl)-1H-pyrazole compound as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry and pharmacotherapeutics. The invention provides application of a compound shown as a formula I or pharmaceutically acceptable salt thereof in preparation of drugs for treating tumor-related diseases, particularly an application in preparation of an Aurora A kinase specific inhibitor.