50656-77-4 Usage
Description
Niranthin, also known as rac-Niranthin, is a lignan compound derived from the plant Phyllanthus amarus. It exhibits various biological activities, including anti-leishmanial properties and the ability to reduce uric acid concentrations through xanthine oxidase inhibition.
Uses
Used in Pharmaceutical Industry:
Niranthin is used as an anti-leishmanial agent for its ability to induce topoisomerase I-mediated DNA-protein adduct formation in Leishmania cells, leading to the apoptosis of cellular nucleases. This makes it a potential candidate for the treatment of leishmaniasis, a disease caused by protozoan parasites of the genus Leishmania.
Used in Gout Treatment:
In the pharmaceutical industry, Niranthin is also used as a treatment for gout due to its ability to reduce uric acid concentrations through the inhibition of xanthine oxidase. This helps alleviate the symptoms and complications associated with gout, a form of arthritis caused by the accumulation of uric acid crystals in the joints.
Used in Antileishmanial Applications:
Niranthin is employed as an antileishmanial agent, specifically targeting Leishmania parasites responsible for leishmaniasis. It acts by inducing topoisomerase I-mediated DNA-protein adduct formation, triggering apoptosis of cellular nucleases and effectively combating the infection.
Used in Uric Acid Reduction:
Niranthin is used as a uric acid reducer, as it inhibits xanthine oxidase, an enzyme involved in the production of uric acid. This application is particularly relevant for the treatment of conditions like gout, where elevated uric acid levels can lead to the formation of painful crystals in the joints.
Check Digit Verification of cas no
The CAS Registry Mumber 50656-77-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,6,5 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 50656-77:
(7*5)+(6*0)+(5*6)+(4*5)+(3*6)+(2*7)+(1*7)=124
124 % 10 = 4
So 50656-77-4 is a valid CAS Registry Number.
50656-77-4Relevant articles and documents
Asymmetric total synthesis of four bioactive lignans using donor-acceptor cyclopropanes and bioassay of (?)- and (+)-niranthin against hepatitis B and influenza viruses
Karasawa, Daichi,Nishii, Yoshinori,Oshima, Mizuki,Ota, Ryotaro,Shimasaki, Noriko,Watashi, Koichi
, p. 4635 - 4639 (2022/02/19)
The asymmetric total synthesis of four lignans, dimethylmatairesinol, matairesinol, (?)-niranthin, and (+)-niranthin has been achieved using reductive ring-opening of cyclopropanes. Moreover, we performed bioassays of the synthesized (+)- and (?)-niranthins using hepatitis B and influenza viruses, which revealed the relationship between the enantiomeric structure and the anti-viral activity of niranthin.
