5057-99-8 Usage
Description
(+/-)-TRANS-1,2-CYCLOPENTANEDIOL, also known as (1R,2R)-rel-trans-1,2-cyclopentanediol, is a versatile organic compound that serves as a key building block in the synthesis of various chemical structures. It is characterized by its cyclopentane ring and two hydroxyl groups in a trans configuration, which allows for a wide range of applications in different industries.
Uses
Used in Pharmaceutical Industry:
(+/-)-TRANS-1,2-CYCLOPENTANEDIOL is used as a building block for the synthesis of chiral phosphine ligands, which are essential in the development of enantioselective catalysts. These catalysts play a crucial role in the production of pharmaceuticals, as they enable the selective synthesis of specific enantiomers with desired biological activity.
Used in Chemical Synthesis:
(+/-)-TRANS-1,2-CYCLOPENTANEDIOL is used as a precursor in the preparation of benzoquinolines and benzoindoles. These heterocyclic compounds are synthesized through the heterocyclization of naphthylamines with diols, catalyzed by iridium chloride/BINAP. Benzoquinolines and benzoindoles are valuable intermediates in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and dyes.
Check Digit Verification of cas no
The CAS Registry Mumber 5057-99-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,5 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5057-99:
(6*5)+(5*0)+(4*5)+(3*7)+(2*9)+(1*9)=98
98 % 10 = 8
So 5057-99-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H10O2/c6-4-2-1-3-5(4)7/h4-7H,1-3H2
5057-99-8Relevant articles and documents
Photo-Induced Dihydroxylation of Alkenes with Diacetyl, Oxygen, and Water
Masuda, Yusuke,Ikeshita, Daichi,Murakami, Masahiro
, (2021/02/09)
Herein reported is a photo-induced production of vicinal diols from alkenes under mild reaction conditions. The present dihydroxylation method using diacetyl (= butane-2,3-dione), oxygen, and water dispenses with toxic reagents and intractable waste generation.
Selective transition-metal-free vicinal cis-dihydroxylation of saturated hydrocarbons
Bering, Luis,Antonchick, Andrey P.
, p. 452 - 457 (2016/12/30)
A transition-metal-free cis-dihydroxylation of saturated hydrocarbons under ambient reaction conditions has been developed. The described approach allows a direct and selective synthesis of vicinal diols. The new reaction thereby proceeds via radical iodination and a sequence of oxidation steps. A broad scope of one-pot dual C(sp3)-H bond functionalization for the selective synthesis of vicinal syn-diols was demonstrated.
Hot water-promoted ring-opening of epoxides and aziridines by water and other nucleopliles
Wang, Zhi,Cui, Yong-Tao,Xu, Zhao-Bing,Qu, Jin
, p. 2270 - 2274 (2008/09/19)
Effective hydrolysis of epoxides and aziridines was conducted by heating them in water at 60 or 100 °C. Other types of nucleophile such as amines, sodium azide, and thiophenol could also efficiently open epoxides and aziridines in hot water. It was proposed that hot water acted as a modest acid catalyst, reactant, and solvent in the hydrolysis reactions.