503-01-5 Usage
Description
Isometheptene is a chemical compound with the molecular formula C11H21N and is classified as a sympathomimetic amine. It exhibits very little antihypertensive activity and is primarily known for its antispasmodic properties.
Uses
Used in Pharmaceutical Industry:
Isometheptene is used as an intermediate for the synthesis of Isometheptene Maleate (I821325), which is an antispasmodic drug. isometheptene is particularly effective in treating conditions that involve muscle spasms or cramps, providing relief and improving the quality of life for patients.
Used in Chemical Synthesis:
As an intermediate, isometheptene plays a crucial role in the production of various chemical compounds, including Isometheptene Maleate. Its involvement in chemical synthesis contributes to the development of new drugs and pharmaceutical products with potential therapeutic applications.
Originator
Octinum,Knoll,US,1948
Manufacturing Process
Methyl heptenone dissolved in 75% alcohol is reduced with activated
aluminum in the presence of methylamine to give isometheptene.
Therapeutic Function
Muscle relaxant
Check Digit Verification of cas no
The CAS Registry Mumber 503-01-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 3 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 503-01:
(5*5)+(4*0)+(3*3)+(2*0)+(1*1)=35
35 % 10 = 5
So 503-01-5 is a valid CAS Registry Number.
503-01-5Relevant articles and documents
Enabling New Modes of Reactivity via Constrictive Binding in a Supramolecular-Assembly-Catalyzed Aza-Prins Cyclization
Kaphan, David M.,Toste, F. Dean,Bergman, Robert G.,Raymond, Kenneth N.
supporting information, p. 9202 - 9205 (2015/08/18)
Supramolecular assembly 1 catalyzes a bimolecular aza-Prins cyclization featuring an unexpected transannular 1,5-hydride transfer. This reaction pathway, which is promoted by constrictive binding within the supramolecular cavity of 1, is kinetically disfavored in the absence of 1, as evidenced by the orthogonal reactivity observed in bulk solution. Mechanistic investigation through kinetic analysis and isotopic labeling studies indicates that the rate-limiting step of the transformation is the encapsulation of a transient iminium ion and supports the proposed 1,5-hydride transfer mechanism. This represents a rare example of such an extreme divergence of product selectivity observed within a catalytic metal-ligand supramolecular enzyme mimic.
