500028-15-9Relevant articles and documents
Lambert Salt-Initiated Development of Friedel–Crafts Reaction on Isatin to Access Distinct Derivatives of Oxindoles
Khan, Jabir,Tyagi, Aparna,Yadav, Naveen,Mahato, Rina,Hazra, Chinmoy K.
, p. 17833 - 17847 (2021/12/17)
Herein, a mild metal-free and efficacious route for the synthesis of biologically important 3-aryl oxindole derivatives is described. Using Lambert salt-initiated hydroarylation of isatin, a diverse array of monoarylated products, symmetrical/unsymmetrical double-arylated products, and deoxygenated hydroarylated products could be synthesized from the single starting substrate in good to excellent yields. A preliminary mechanistic study revealed that the reaction proceeds via a monoarylated product followed by a nucleophilic attack by another electron-rich arene nucleophile under mild conditions. The potential of newly synthesized symmetric/unsymmetric 3,3-disubstituted oxindole, 3-substituted 3-hydroxy oxindoles, 3,3-di(indolyl)indolin-2-ones, and α-aryl oxindoles as valuable building blocks is further illustrated.
Synthesis, characterization, and modification of hyperbranched poly(arylene oxindoles) with a degree of branching of 100%
Smet, Mario,Schacht, Etienne,Dehaen, Wim
, p. 4547 - 4550 (2007/10/03)
Excellent thermal stability and a relatively high glass-transition temperature are exhibited by the hyperbranched poly(arylene oxindoles), which were prepared by an acidcatalyzed polycondensation of the substituted isatine 1. The polymers thus obtained ca
