50-34-0 Usage
Description
Propantheline bromide, also known as Pro-Banthine, is a white, water-soluble, crystalline substance with chemical properties similar to methantheline bromide. It is an antimuscarinic agent and a muscarinic acetylcholine receptor antagonist, which makes it useful in various medical applications due to its anticholinergic effects.
Uses
Used in Pharmaceutical Industry:
Propantheline bromide is used as an anticholinergic agent for treating conditions such as hyperhidrosis (excessive sweating), enuresis (involuntary urination), and cramps or spasms of the stomach, intestine, and bladder. Its anticholinergic properties help in managing these conditions by blocking the action of acetylcholine, a neurotransmitter responsible for muscle contractions and various other functions.
Used in Antimuscarinic Applications:
As an antimuscarinic agent, propantheline bromide is employed to alleviate symptoms caused by excessive stimulation of muscarinic acetylcholine receptors. This includes conditions like peptic ulcers, irritable bowel syndrome, and certain gastrointestinal disorders where muscle spasms and cramps need to be controlled.
Used in Drug Formulation:
Propantheline bromide is used as an active pharmaceutical ingredient in the formulation of various medications aimed at treating the aforementioned conditions. Its potent anticholinergic effects make it a valuable component in the development of drugs for gastrointestinal and urinary disorders.
Air & Water Reactions
Water soluble.
Health Hazard
SYMPTOMS: Symptoms of exposure to Propantheline bromide include dilated pupils and blurred vision; increased intraocular tension and heart rate; hot, dry, red skin; dry mouth; disorientation; hallucinations; aggressive behavior; rapid pulse and respiration; convulsions; and coma.
Fire Hazard
Flash point data are not available for Propantheline bromide , but Propantheline bromide is probably combustible.
Biochem/physiol Actions
Inhibits action of acetylcholine at post-ganglionic synapses; muscarinic acetylcholine receptor antagonist; antispasmodic; reduces gastric acid secretion.
Veterinary Drugs and Treatments
In small animal medicine propantheline bromide has been used for
its antispasmodic/antisecretory effects in the treatment of diarrhea.
It is also employed in the treatment of hyperreflexic detrusor or
urge incontinence and as oral treatment in anticholinergic responsive
bradycardias. In horses, propantheline has been used intravenously
to reduce colonic peristalsis and for relaxing the rectum to
allow easier rectal examination and surgery.
Check Digit Verification of cas no
The CAS Registry Mumber 50-34-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 50-34:
(4*5)+(3*0)+(2*3)+(1*4)=30
30 % 10 = 0
So 50-34-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H
