4876-59-9

Basic information

• Product Name: 4-(dimethylammonio)piperidinium dichloride
• Synonyms: 4-(dimethylammonio)piperidinium dichloride;4-(Dimethylamino)piperidine dihydrochloride;4-DIMETHYLAMINOPIPERIDINE 2HCL;4-(Dimethylamino)piperidine dihydrochloride,98%;Dimethyl-piperidin-4-yl-amine dihydrochloride;N,N-dimethylpiperidin-4-amine dihydrochloride;Dimethyl-piperidin-4-yl-amine dihydorochloride;DiMethyl-piperidin-4-yl-aMine di, HCl
• CAS NO: 4876-59-9
• Molecular Formula: C₇H₁₆N₂*2ClH
• Molecular Weight: 201.13722
• EINECS: 225-486-3
• Mol File: 4876-59-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 288-290℃
• Boiling Point: 179.7°Cat760mmHg
• Flash Point: 63.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.929mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(dimethylammonio)piperidinium dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(dimethylammonio)piperidinium dichloride(4876-59-9)
• EPA Substance Registry System: 4-(dimethylammonio)piperidinium dichloride(4876-59-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 4876-59-9(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Dimethyl-piperidin-4-yl-amine DiHCl

InChI:InChI=1/C7H16N2.ClH/c1-9(2)7-3-5-8-6-4-7;/h7-8H,3-6H2,1-2H3;1H/p-1

Upstream product

• 412293-88-0 4-dimethylaminopiperidine-1-carboxylic acid tert-butyl ester 
• 4876-56-6 1-benzyl-N,N-dimethylpiperidin-4-amine dihydrochloride 

Downstream Products

• 1251838-36-4 (4-(dimethylamino)piperidin-1-yl)(4-nitrophenyl)methanone hydrochloride 
• 211247-62-0 [1-(4-Amino-phenyl)-piperidin-4-yl]-dimethyl-amine 
• 1237519-66-2 tert-butyl 2-(2-(benzyloxy)-5-(4-(dimethylamino)piperidin-1-yl)benzamido)-4-phenylbenzoate 
• 1237519-67-3 tert-butyl 2-(5-(4-(dimethylamino)piperidin-1-yl)-2-hydroxybenzamido)-4-phenylbenzoate 
• 59528-74-4 4-dimethylamino-1-[4-(7-chloro-4-quinolylamino)-benzenesulphonyl]piperidine 
• 882679-00-7 N,N-dimethyl-1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-4-amine 
• 211247-60-8 N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine 

Relevant articles and documents

Gedatolisib intermediates for preparation of (by machine translation)

The invention belongs to the organic synthesis and bulk drug intermediate preparation field, in particular to a method for preparing Gedatolisib, key intermediate and a key intermediate in the preparation method. The nitrobenzene nitrile and dicyanodiamine polyisobutylene triazine cyclization, morpholine link guan huan, hydrogenation of nitro reduction to obtain 4 - (4, 6 - II morpholino - 1, 3, 5 - triazine - 2 - yl) aniline; 4 - oxo-piperidine - 1 - carboxylic acid tert-butyl and dimethylamine salt by addition, de-Boc protecting group, amide, hydrogenation of nitro reduction to get new compounds (4 - aminophenyl) (4 - (dimethyl amino) piperidine - 1 - yl) methyl ketone; adopts the one-pot synthesis, (4, 6 - II morpholino - 1, 3, 5 - triazine - 2 - yl) aniline and chloromethane acid ester after the reaction, then adding (4 - aminophenyl) (4 - (dimethyl amino) piperidine - 1 - yl) methanone, to finally obtain the Gedatolisib. This preparation method has the advantages of easy availability of raw materials, process is simple, easy to operate, high yield and low cost and the like. (by machine translation)

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the generalformula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable saltthereof. They are useful as a therapeutic/preventive agent for diabetes, diabeticnephropathy, or glomerulosclerosis.

NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE

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