480439-44-9

Basic information

• Product Name: 2-BROMO-4-FLUOROPHENYL ACETATE 97
• Synonyms: 2-BROMO-4-FLUOROPHENYL ACETATE 97;2-bromo-4-fluorophenyl acetate
• CAS NO: 480439-44-9
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.03
• Mol File: 480439-44-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 95 °C4.2 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /solid
• Density: 1.572 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0196mmHg at 25°C
• Refractive Index: n20/D 1.514(lit.)
• CAS DataBase Reference: 2-BROMO-4-FLUOROPHENYL ACETATE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-FLUOROPHENYL ACETATE 97(480439-44-9)
• EPA Substance Registry System: 2-BROMO-4-FLUOROPHENYL ACETATE 97(480439-44-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 480439-44-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6BrFO2/c1-5(11)12-8-3-2-6(10)4-7(8)9/h2-4H,1H3

Upstream product

• 496-69-5 2-bromo-4-fluoro-phenol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 

Downstream Products

• 393-62-4 1-(3-bromo-5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 790710-81-5 ethyl 8-bromo-6-fluoro-4-oxo-4H-chromene-2-carboxylate 
• 790710-83-7 1-[5-fluoro-2-hydroxy-3-(4-methylpiperazin-1-yl)phenyl]ethanone 
• 1089706-28-4 1-(5-bromo-3-fluoro-2-hydroxyphenyl)ethan-1-one 
• 67274-77-5 4-fluoro-2-(pyridin-2-yl)phenol 
• 862742-96-9 acetic acid 4-fluoro-2-pyridin-2-yl-phenyl ester 

Relevant articles and documents

ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES ASSOCIATED WITH P13K MODULATION

The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I), or a prodrug, solvate, enantiomer, st

Successful development and scale-up of a palladium-catalysed amination process in the manufacture of ZM549865

Key steps in the synthesis of ZM549865 (a 5-HT receptor antagonist) are the palladium-catalysed amination of ethyl 8-bromo-6-fluoro-4-oxo-4H-2- chromenecarboxylate and subsequent hydrolysis of the ester group. The development of a simple, robust process c